Pathogenesis sequences in Gejiu miners with lung cancer: an introduction

Abstract

Tin miners in Gejiu, Yunnan Province, China are at high risk of developing lung cancer with significant occupational characteristics. Tissue samples from these miners presented pathological characteristics, such as fibroplasia in carcinomas, peri-cancerous tissue in lung cancers, and hyperplasia and dysplasia of epithelial cells in peri-cancerous tissue. Carcinomas induced by Yunnan tin mine dust in the animal experiment underwent inflammation, fibroplasia, hyperplasia, dysplasia, and carcinogenesis of epithelial cells. A correlated and synergistic relationship was observed between bronchial epithelial cell transformation and fibroblast activation in vitro induced by mine dust. Fibroblast hyperplasia and activation are important factors that promote the transformation and carcinogenesis of epithelial cells. Our findings suggested that pulmonary fibrosis may increase the risk and promote the occurrence of lung cancer, which can lead to lung fiber hyperplasia.

Keywords

Yunnan tin mine / miners / lung cancer

References

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Acknowledgements

We thank Dr. Xianbo Zhou for his assistance with the final manuscript. This project was supported by two grants from the National Natural Science Foundation of China (81460355 and 81160276) and two grants from the Department of Science and Technology of Yunnan Province, Kunming Medical University Collaborative Special Projects (2014FB020 and 2011FB181).

Compliance with ethics guidelines

Li Bian, Yonghua Ruan, Liju Ma, Hairong Hua, Li Zhou, Xiaoyu Tuo, Zheyan Zhou, Ting Li, Shiyue Liu, and Kewei Jin declare no conflict of interest. Informed consent was obtained from the patients prior to inclusion in this study.

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2014 Higher Education Press and Springer-Verlag Berlin Heidelberg