Gender differences in the relationship between plasma lipids and fasting plasma glucose in non-diabetic urban Chinese population: a cross-section study

Abstract

The association between dyslipidemia and elevated fasting glucose in type 2 diabetes is well known. In non-diabetes, whether this association still exists, and whether dyslipidemia is an independent risk factor for high fasting plasma glucose (FPG) levels are not clear. This cross-sectional study recruited 3460 non-diabetic Chinese subjects (1027 men, and 2433 women, aged 35–75 years old) who participated in a health survey. Men and women were classified into tertiles by levels of plasma lipids respectively. In women, the prevalence of impaired fasting glucose (IFG) was decreased with increased HDL-C. A stepwise increase in HDL-C was associated with decreasing FPG levels (lowest tertiles, FPG: 5.376±0.018; middle tertiles, 5.324±0.018; highest tertiles, 5.276±0.018 mmol/L; P=0.001). Reversely, FPG levels increased from lowest tertiles to highest tertiles of LDL-C, TC, and TG. we found that women in the first tertile with lower HDL-C level had a 1.75-fold increase in risk of IFG compared with non-diabetic women in the third tertile with higher HDL-C level (OR: 1.75; 95% CI: 1.20--2.56). In men, no significant association was found. We took age, BMI, waist/hip ratio, education, smoking, alcohol drinking, and physical exercise as adjusted variables. In Chinese non-diabetic women, dyslipidemia is independently associated with high levels of FPG; TG, HDL-C, and LDL-C are predictors of IFG independent of BMI and waist/hip ratio.

Keywords

dyslipidemia / plasma lipids / plasma fasting glucose / impaired fasting glucose / non-diabetes

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Acknowledgements

We appreciate the cooperation of study participants and many investigators in the Second Hospital of Shanxi Medical University.

Compliance with ethics guidelines

Jie Zheng, Yuzhen Gao, Yuejuan Jing, Xiaoshuang Zhou, Yuanyuan Shi, Yanhong Li, Lihua Wang, Ruiying Wang, Maolian Li, Chuanshi Xiao, Yafeng Li, and Rongshan Li declare that they have no conflict of interest. The protocol for the study was reviewed and approved by Medical Ethics Committee in the Second Hospital of Shanxi Medical University. All subjects participated in physical examination voluntarily. This study was conducted in accordance with the Helsinki Declaration under the supervision of clinical investigators. The subjects provided informed consent, including their permission for the findings to be published.

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