Regulation and function of histone acetyltransferase MOF
Yang Yang , Xiaofei Han , Jingyun Guan , Xiangzhi Li
Front. Med. ›› 2014, Vol. 8 ›› Issue (1) : 79 -83.
Regulation and function of histone acetyltransferase MOF
The mammalian MOF (male absent on the first), a member of the MYST (MOZ, YBF2, SAS2, and Tip60) family of histone acetyltransferases (HATs), is the major enzyme that catalyzes the acetylation of histone H4 on lysine 16. Acetylation of K16 is a prevalent mark associated with chromatin decondensation. MOF has recently been shown to play an essential role in maintaining normal cell functions. In this study, we discuss the important roles of MOF in DNA damage repair, apoptosis, and tumorigenesis. We also analyze the role of MOF as a key regulator of the core transcriptional network of embryonic stem cells.
MOF / histone acetyltransferase / DNA damage repair / tumorigenesis / embryonic stem cells
Higher Education Press and Springer-Verlag Berlin Heidelberg
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