Regulation and function of histone acetyltransferase MOF

Abstract

The mammalian MOF (male absent on the first), a member of the MYST (MOZ, YBF2, SAS2, and Tip60) family of histone acetyltransferases (HATs), is the major enzyme that catalyzes the acetylation of histone H4 on lysine 16. Acetylation of K16 is a prevalent mark associated with chromatin decondensation. MOF has recently been shown to play an essential role in maintaining normal cell functions. In this study, we discuss the important roles of MOF in DNA damage repair, apoptosis, and tumorigenesis. We also analyze the role of MOF as a key regulator of the core transcriptional network of embryonic stem cells.

Keywords

MOF / histone acetyltransferase / DNA damage repair / tumorigenesis / embryonic stem cells

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Acknowledgements

We gratefully acknowledge the financial support from the National Natural Science Foundation of China (Grant No. 31171428) and the Program for New Century Excellent Talents in University (NCET).

Compliance with ethics guidelines

Yang Yang, Xiaofei Han, Jingyun Guan, and Xiangzhi Li declare that they have no conflict of interest. All institutional and national guidelines for the care and use of laboratory animals were followed. Animal care was in strict compliance with the institutional guidelines of the Shandong University School of Medicine. All animal procedures were approved by the Institutional Animal Care and Use Committee of the Shandong University School of Medicine. Our experiments are always conducted in accordance with the principles of experimental animal welfare and ethics.

RIGHTS & PERMISSIONS

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg