Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected skin diseases

Xinghua Gao, Hongduo Chen

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Front. Med. ›› 2014, Vol. 8 ›› Issue (1) : 1-5. DOI: 10.1007/s11684-014-0309-3
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Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected skin diseases

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Abstract

Hyperthermia is a condition characterized by increased body temperature as a consequence of failed thermoregulation. Hyperthermia occurs when a body produces or absorbs more heat than it dissipates. Hyperthermia also elicits various effects on the physiology of living cells. For instance, fever-range temperature (39β°C to 40β°C) can modulate the activities of immune cells, including antigen-presenting cells, T cells, and natural killer cells. Heat shock temperature (41β°C to 43β°C) can increase the immunogenicity of tumor cells. Cytotoxic temperature (>43β°C) can create an antigen source to induce an anti-tumor immune response. The immunomodulatory effect of hyperthermia has promoted an interest in hyperthermia-aided immunotherapy, particularly against tumors. Hyperthermia has also been used to treat deep fungal, bacterial, and viral skin infections. We conducted a series of open or controlled trials to treat skin human papillomavirus infection by inducing local hyperthermia. More than half of the patients were significantly cured compared with those in the control trial. A series of challenging clinical cases, such as large lesions in pregnant patients or patients with diabetes mellitus, were also successfully and safely managed using the proposed method. However, further studies should be conducted to clarify the underlying mechanisms and promote the clinical applications of hyperthermia.

Keywords

hyperthermia / HPV / immune response / virus / tumor

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Xinghua Gao, Hongduo Chen. Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected skin diseases. Front. Med., 2014, 8(1): 1‒5 https://doi.org/10.1007/s11684-014-0309-3

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Acknowledgements

This study was supported by the Innovative Research Teams of Liaoning Department of Education (Grant No. LT2011012) and Public Welfare Research Fund for Healthcare (No.201202013).
Compliance with ethics guidelines
Xinghua Gao and Hongduo Chen declare that they have no conflict of interest. This manuscript is a review article and does not involve a research protocol requiring approval by the relevant institutional review board or ethics committee.

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2014 Higher Education Press and Springer-Verlag Berlin Heidelberg
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