Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis
Shuangwei Li , Diane DiFang Hsu , Hongyang Wang , Gen-Sheng Feng
Front. Med. ›› 2012, Vol. 6 ›› Issue (3) : 275 -279.
Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis
PTPN11, which encodes tyrosine phosphatase Shp2, is a critical gene mediating cellular responses to hormones and cytokines. Against original prediction as tumor suppressor for tyrosine phosphatases, PTPN11 was first identified as a proto-oncogene because activating mutations of this gene are associated with leukemogenesis. However, most recent experimental data suggest PTPN11/Shp2 acting as a tumor suppressor in hepatocarcinogenesis. This review focuses on the tumor-promoting or suppressing roles of the gene PTPN11/Shp2 in different cell types.
PTPN11/Shp2 / leukemia / hepatocellular carcinoma / mutation
Higher Education Press and Springer-Verlag Berlin Heidelberg
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