The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Abstract

Protein kinase C epsilon (PKC ϵ) is one of major isoforms in novel PKC family. Although it has been extensively characterized in the past decade, the role of PKC ϵ in neuron is still not well understood. Advances in molecular biology have now removed significant barriers to the direct investigation of PKC ϵ functions in vivo, and PKC ϵ has been increasingly implicated in the neural biological functions and associated neurogenic diseases. Recent studies have provided important insights into the influence of PKC ϵ on cortical processing at both the single cell level and network level. These studies provide compelling evidence that PKC ϵ could regulate distinct aspects of neural signal transduction and suggest that the coordinated actions of a number of molecular signals contribute to the specification and differentiation of PKC ϵ signal pathway in the developing brain.

Keywords

protein kinase C ϵ / signal transduction / neurogenic disease

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