Stem cell niches and endogenous electric fields in tissue repair

Abstract

Adult stem cells are responsible for homeostasis and repair of many tissues. Endogenous adult stem cells reside in certain regions of organs, known as the stem cell niche, which is recognized to have an important role in regulating tissue maintenance and repair. In wound healing and tissue repair, stem cells are mobilized and recruited to the site of wound, and participate in the repair process. Many regulatory factors are involved in the stem cell-based repair process, including stem cell niches and endogenous wound electric fields, which are present at wound tissues and proved to be important in guiding wound healing. Here we briefly review the role of stem cell niches and endogenous electric fields in tissue repair, and hypothesize that endogenous electric fields become part of stem cell niche in the wound site.

Keywords

stem cell / stem cell niche / electric field / tissue repair

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Acknowledgements

We are very grateful to Professor Min Zhao (University of California, Davis) for his great help of critical reading of the manuscript. This work is supported by Key Program of National Nature Science Foundation of China (81030037) and Open fund of State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University (SKLZZ200804).

RIGHTS & PERMISSIONS

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg