Cyclooxygenase-2 gene-1195G/A genotype is associated
with the risk of HBV-induced HCC: A case-control study in Han Chinese
people

doi:10.1007/s11684-010-0021-x

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Front. Med. ›› 2010, Vol. 4 ›› Issue (1) : 90-95. DOI: 10.1007/s11684-010-0021-x

Research articles

Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC: A case-control study in Han Chinese people

Li-Feng LIU MD, PhD¹,Qiong CHEN MD, PhD¹,Ying CHANG MD, PhD¹,Ju-Sheng LIN MD, PhD¹,Jin-Liang ZHANG MM²,

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Abstract

This study aimed to identify functional single nucleotide polymorphisms in the cyclooxygenase-2 gene promoter and evaluate their effects on the risk of primary hepatocellular carcinoma (HCC) with hepatitis B virus (HBV) infection. We conducted a population-based, case-control study enrolling 630 Han Chinese people in Hubei province. Subjects included primary HCC patients with HBV infection (n=210), chronic hepatitis B cases (n=210) and healthy Han Chinese (n=210). -1195G/A polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and sequencing analysis. We found-1195A allele carriers had a higher risk of HCC with HBV infection (OR, 0.72; 95% CI, 0.548–0.946). The-1195A allele might be used as a marker in screening individuals at high risk of HCC with HBV infection.

Keywords

cyclooxygenase-2 gene / single nucleotide polymorphisms / susceptibility / primary hepatocellular carcinoma / hepatitis B virus infection

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Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,. Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC: A case-control study in Han Chinese people. Front. Med., 2010, 4(1): 90‒95 https://doi.org/10.1007/s11684-010-0021-x