Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive effect of Arachidonic acid on insulin resistance

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

doi:10.1007/s11684-007-0038-y

Front. Med. ›› 2007, Vol. 1 ›› Issue (2) : 200 -206. DOI: 10.1007/s11684-007-0038-y

Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive effect of Arachidonic acid on insulin resistance

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

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Abstract

Elevated plasma levels of free fatty acids (FFAs) may contribute to insulin resistance (IR) that is characteristic of type 2 diabetes mellitus. In this study, we investigated the effects of two fatty acids, palmitate (PA) and arach

Keywords

insulin resistance / palmitate / protein kinase B / glycogen synthase / arachidonic acid

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XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing. Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive effect of Arachidonic acid on insulin resistance. Front. Med., 2007, 1(2): 200-206 DOI:10.1007/s11684-007-0038-y