A new supercritical fluid (SCF) technique was developed for the preparation of microspheres for pulmonary drug delivery (PDD). This technique, based on the anti-solvent process, has incorporated advanced engineering design features to enable improved control of the particle formation process. Human recombinant insulin (HRI) was used as a model compound to evaluate the efficiency of this SCF process. An aqueous solution of HRI with a co-solvent was sprayed into high pressure carbon dioxide that extracted the solvent and water, leading to a dry fine powder with good particle size distribution and near ideal morphology for pulmonary drug delivery.
Yongda SUN,
. Protein microspheres for pulmonary drug delivery[J]. Frontiers of Chemical Science and Engineering, 2010
, 4(1)
: 82
-86
.
DOI: 10.1007/s11705-009-0307-1