Frontiers of Chemical Science and Engineering >
FBRM and PVM investigations of the double feed semi-batch crystallization of 6-aminopenicillanic acid
Received date: 07 Dec 2008
Accepted date: 12 Feb 2009
Published date: 05 Sep 2009
Copyright
6-Aminopenicillanic acid (6-APA) is a crucial pharmaceutical intermediate in the chemistry of semi-synthetic antibiotics. The focused beam reflectance measurement (FBRM) technology and particle vision measurement (PVM) technology were employed to the processes of online-monitoring of 6-APA crystallization behavior in a double-feeding semi-batch crystallizer. Experiments were carried out with four kinds of double-feeding policies and the results were compared with the traditional single-feeding. Records and analysis of FBRM indicated that the nucleation of double feeding policy was much higher than single policy, and chord length of 6-APA was almost determined and had little change after the nucleation peak. Ostwald ripening process had no significant effect on further growth of 6-APA crystal. PVM images showed that the crystal habit of 6-APA was continuously changed during the crystallization process. The development of (002) face in the final crystal for the five feeding policies were different.
Key words： 6-aminopenicillanic acid; crystallization; double-feeding; FBRM; PVM; crystal habit
Min SU , Lin WANG , Hua SUN , Jingkang WANG . FBRM and PVM investigations of the double feed semi-batch crystallization of 6-aminopenicillanic acid[J]. Frontiers of Chemical Science and Engineering, 2009 , 3(3) : 282 -288 . DOI: 10.1007/s11705-009-0018-7
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