Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Abstract

Polymethacrylic acid (PMA) was synthesized on the backbone of psyllium (Psy) by a microwave assisted method to prepare polymeric grafted materials designated as (Psy-g-PMA). Various grades of Psy-g-PMA were prepared by changing the degree of grafting from 35%–58% and the materials were then made into tablets. Swelling and biodegradability studies of the tablets were carried out. Acetyl salicylic acid was incorporated in the various Psy-g-PMA samples and tablets were prepared to study the in vitro drug release in acidic (pH= 4), neutral (pH= 7), and basic (pH= 9) media. In the acidic medium, the swelling was more than 1300%. In addition, the biodegradable Psy-g-PMA had the highest drug release in the acidic medium. This may be attributed to Fickian diffusion since the drug and the medium in which it was released have the same acidic nature.

Key words： psyllium; acetyl salicylic acid; in-vitro drug release; swelling; biodegradation

Acknowledgments

The authors gratefully acknowledge the generous and kind cooperation of Dr. Rakesh Kumar, Assistant Professor, Department of Applied Chemistry, Birla Institute of Technology, Mesra, Ranchi, Patna Campus India for helping in the preparation of this manuscript.

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