Frontiers of Chemical Science and Engineering >
Enhanced penetration strategies for transdermal delivery
Received date: 12 May 2019
Accepted date: 04 Dec 2019
Published date: 15 Jun 2020
Copyright
Transdermal delivery offers several advantages in drug distribution, including convenience, painless administration, avoidance of first-pass metabolism, and ease of termination. However, the natural protective barriers of the skin, such as the stratum corneum, the topmost layer of skin, limit the systemic absorption of external therapeutics via transdermal delivery. Therefore, extensive application of transdermal delivery in medical treatment has been limited. Over the past few years, many formulation strategies and physical technologies, therefore, have been developed to enhance transdermal delivery. This review summarizes various formulation strategies proposed for transdermal delivery and their application in medical treatment.
Key words: transdermal delivery; stratum corneum; enhanced penetration; therapeutics
Qiaofei Pan , Yinglin Yu , Dong Chen , Genlong Jiao , Xiaowen Liu . Enhanced penetration strategies for transdermal delivery[J]. Frontiers of Chemical Science and Engineering, 2020 , 14(3) : 378 -388 . DOI: 10.1007/s11705-019-1913-1
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