Frontiers of Chemical Science and Engineering >

2016 , Vol. 10 >Issue 2: 245 - 254

DOI: https://doi.org/10.1007/s11705-016-1569-z

RESEARCH ARTICLE

The solubility of cefquinome sulfate in pure and mixed solvents

  • Rongbao Qi 1,2 ,
  • Jingkang Wang 1,2 ,
  • Junxiao Ye 1,2 ,
  • Hongxun Hao , 1,2 ,
  • Ying Bao 1,2
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  • 1. State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
  • 2. Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin), Tianjin 300072, China

Received date: 09 Nov 2015

Accepted date: 03 Mar 2016

Published date: 19 May 2016

Copyright

2016 Higher Education Press and Springer-Verlag Berlin Heidelberg
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Abstract

Solid-liquid equilibrium data of cefquinome sulfate is important to develop industrial crystallization processes for cefquinome sulfate. The solubilities of cefquinome sulfate in five pure solvents (methanol, ethanol, ethylene glycol, acetic acid and water) from 277.15 to 305.15 K and in a binary acetone-water solvent from 278.15 to 293.15 K were measured at atmospheric pressure. The pure-solvent solubility data was correlated to the modified Apelblat and Van’t Hoff equations whereas the mixed-solvent system data was correlated to the modified Apelblat, Van’t Hoff, CNIBS/R-K and Jouyban-Acree models. It was found that the solubilities of cefquinome sulfate in all tested solvents decreased with the increasing of temperature. In addition, the thermodynamic properties of the dissolution processes, including standard Gibbs free energy, enthalpy and entropy changes, were calculated using the Van’t Hoff equation. It was found that the dissolution of cefquinome sulfate is exothermic.

Key words： cefquinome sulfate; solubility; thermodynamic properties

Cite this article

Rongbao Qi , Jingkang Wang , Junxiao Ye , Hongxun Hao , Ying Bao . The solubility of cefquinome sulfate in pure and mixed solvents[J]. Frontiers of Chemical Science and Engineering, 2016 , 10(2) : 245 -254 . DOI: 10.1007/s11705-016-1569-z

Acknowledgment

This research was financially supported by the National Natural Science Foundation of China (No. 21376165), the Key Project of Tianjin Science and Technology Support Program (No. 13ZCZDNC08900) and the Tianjin Municipal Natural Science Foundation (No. 13JCZDJC28400).

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