REVIEW ARTICLE

Semi-solid materials for controlled release drug formulation: current status and future prospects

  • Michelle TRAN ,
  • Chun WANG
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  • Department of Biomedical Engineering, University of Minnesota, 7-105 Hasselmo Hall, 312 Church Street S.E., Minneapolis, MN 55455, USA

Received date: 22 Jan 2014

Accepted date: 22 Feb 2014

Published date: 22 May 2014

Copyright

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg

Abstract

Semi-solid materials represent an important category of inactive ingredients (excipients) of pharmaceutical products. Here we review several common semi-solid polymers currently used in the controlled release formulations of many drugs. These polymers are selected based on their importance and broad scope of application in FDA-approved drug products and include several polysaccharides (cellulose, starch, chitosan, alginate) and carbomers, a group of mucoadhesive synthetic polymers. Glyceride-based polymers used in self-emulsifying drug delivery systems (SEDDS) will also be discussed for its importance in formulating poorly water-soluble drugs. Unique features and advantages of each type of semi-solid materials are discussed and examples of their use in oral delivery of drugs are provided. Finally, future prospects of developing new and better semi-solid excipients are discussed with the objective of facilitating clinical translation.

Cite this article

Michelle TRAN , Chun WANG . Semi-solid materials for controlled release drug formulation: current status and future prospects[J]. Frontiers of Chemical Science and Engineering, 2014 , 8(2) : 225 -232 . DOI: 10.1007/s11705-014-1429-7

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