Bioorthogonal chemistry based on-demand drug delivery system in cancer therapy

Abstract

Benefiting from the advantage of taking place in biological environments without interfering with an innate biochemical process, the bioorthogonal reaction that commonly contains the “bond formation” and “bond cleavage” system has been widely used in targeted therapy for a variety of tumors. Herein, several prominent cases based on the bioorthogonal reaction that tailoring the metabolic glycoengineering tactics to modified cells for cancer immunotherapy, and the innovative tactics for reducing the metal ions’ toxic and side effects with microneedle patches will be highlighted. Based on these applications, the complexities, potential pitfalls, and opportunities of bioorthogonal chemistry in future cancer therapy will be evaluated.

Graphical abstract

Keywords

bioorthogonal reaction / cancer therapy / metabolic glycoengineering / bioorthogonal catalytic patch

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Acknowledgments

This work was supported by the Major State Basic Research Development Program of China (Grant No. 2017YFA0205201) and the National Natural Science Foundation of China (Grant Nos. 81925019 and U1705281).

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