Hydroxyl radical-involved cancer therapy via Fenton reactions

Abstract

The tumor microenvironment features over-expressed hydrogen peroxide (H₂O₂). Thus, versatile therapeutic strategies based on H₂O₂ as a reaction substrate to generate hydroxyl radical (•OH) have been used as a prospective therapeutic method to boost anticancer efficiency. However, the limited Fenton catalysts and insufficient endogenous H₂O₂ content in tumor sites greatly hinder •OH production, failing to achieve the desired therapeutic effect. Therefore, supplying Fenton catalysts and elevating H₂O₂ levels into cancer cells are effective strategies to improve •OH generation. These therapeutic strategies are systematically discussed in this review. Furthermore, the challenges and future developments of hydroxyl radical-involved cancer therapy are discussed to improve therapeutic efficacy.

Graphical abstract

Keywords

hydroxyl radical / Fenton catalyst / hydrogen peroxide / cancer therapy

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Acknowledgments

The authors acknowledge the financial support from the Tianjin Science and Technology Committee (Grant No. 19JCYBJC28400), the Basic Research General Program of Shenzhen Science and Technology Innovation Commission in 2020 (Grant No. JCYJ20190806162412752).

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