Synthesis and in vivo nematocidal evaluation of novel 3-(trifluoromethyl)-1H-pyrazole-4-carboxamide derivatives

Wen Zhao, Jiahua Xing, Tianming Xu, Weili Peng, Xinghai Liu

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Front. Chem. Sci. Eng. ›› 2017, Vol. 11 ›› Issue (3) : 363-368. DOI: 10.1007/s11705-016-1595-x
RESEARCH ARTICLE

Synthesis and in vivo nematocidal evaluation of novel 3-(trifluoromethyl)-1H-pyrazole-4-carboxamide derivatives

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Abstract

Pyrazole carboxamide derivatives represent an important class of fungicides in agrochemicals. To find more novel structural pyrazole carboxamides, a novel series of 3-(trifluoromethyl)-1H-pyrazole-4-carboxamide compounds were prepared from ethyl 4,4,4-trifluoroacetoacetate and triethyl orthoformate as starting materials. All the products were characterized by Fourier transform infrared spectroscopy, 1H nuclear magnetic resonance (NMR), 13C NMR, 19F NMR and mass spectrography. The bioassay results showed these fluorine-containing pyrazole carboxamides have a weak fungicidal activity but some of them exhibit a good nematocidal activity against M. incognita.

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Keywords

fluorinated pyrazole carboxamide / synthesis / nematocidal activity / structure and activity relationship

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Wen Zhao, Jiahua Xing, Tianming Xu, Weili Peng, Xinghai Liu. Synthesis and in vivo nematocidal evaluation of novel 3-(trifluoromethyl)-1H-pyrazole-4-carboxamide derivatives. Front. Chem. Sci. Eng., 2017, 11(3): 363‒368 https://doi.org/10.1007/s11705-016-1595-x

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Acknowledgements

This work was supported financially by Zhejiang Provincial Science Foundation of China (No. LY16C140007) and Research Institute Special Program of Department of Science and Technology of Zhejiang Province (No. 2015F50030).

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2016 Higher Education Press and Springer-Verlag Berlin Heidelberg
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