One-pot three-component Mannich reaction catalyzed by sucrose char sulfonic acid

Abstract

Sucrose char sulfonic acid efficiently catalyzed the one-pot three-component Mannich reaction of ketones, aromatic aldehydes and amines in ethanol to afford the corresponding b-amino carbonyl compounds in good to excellent yields. A series of heteroaromatic b-amino carbonyl compounds can be obtained when using 2-acetylpyrazine as substrate. This reaction can be performed under mild reaction conditions with clean reaction profiles and a simple workup procedure.

Keywords

One–pot synthesis / b-amino ketone / char sulfonic acid / 2-acetylpyrazine / catalysis

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Acknowledgements

The authors would like to thank the National Natural Science Foundation of China (Grant No. 20572021) for funding support.

RIGHTS & PERMISSIONS

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg