Microwave-assisted synthesis and antimicrobial activities of 2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin-4-ones

Abstract

2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin-4-ones 4 and 5 were synthesized in 41%-67% yield by using microwave-assisted one-pot protocol. The structures of the new compounds 4l, 4m, 5c, 5e, 5g, 5h, and 5j-5m were confirmed by IR, NMR, MS, and elemental analysis. The antimicrobial activities of the compounds against Pseudomonas syringae pv. lachrymans (Smith et Bryan) Young, Dye & Wilkie, Botrytis cinerea Pers., and Sphaerotheca fusca Blum. were examined. Some of the compounds showed good antifungical activity against Sphaerotheca fusca Blum.

Keywords

microwave-assisted synthesis / naphthyl / thiazolidin-4-one / antimicrobial

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Acknowledgements

The financial supports from the National Natural Science Foundation of China (Grant No. 20672027), the Natural Science Foundation of Hebei (2005000106, 2008000588), the Research Foundation of the Ministry of Education of China (206013) and the Postdoctoral Foundation of China are gratefully acknowledged.

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2014 Higher Education Press and Springer-Verlag Berlin Heidelberg