A fast iterative-clique percolation method for identifying functional modules in protein intreaction networks

Abstract

Accumulating evidence suggests that biological systems are composed of interacting, separable, functional modules—groups of vertices within which connections are dense but between which they are sparse. Identifying these modules is likely through capturing the biologically meaningful interactions. In recent years, many algorithms have been developed for detecting such structures. These algorithms, however, are computationally demanding, which limits their applications. In this paper, we propose a fast iterative-clique percolation method (ICPM) for identifying overlapping functional modules in protein-protein interaction (PPI) networks. Our method is based on clique percolation method (CPM), and it not only considers the degree of nodes to minimize the search space (the vertices in k-cliques must have the degree of k

Keywords

iterative-clique percolation method (ICPM) / clique percolation method (CPM) / functional modules / protein-protein interaction (PPI)