With a self-designed peritoneo-venous shunt device, the authors made experimental studies in 10 dogs and 1 monkey which were rendered ascitic by constriction of the vena cava just above the diaphragm. Ascites disappeared in all animals rapidly following insertion of shunt device. From Nov. 1980 to Jan. 1983, this peritoneo-venous shunt device was applied clinically in 24 patients with intractable ascites, among whom 12 developed the disease due to schistosomiasis and 12 were late cases of liver cirrhosis. Ascites disappeared in all cases in 3–14 days with decrease of the abdominal circumference and improvement of the patients’ general condition.

In this study 3 various kinds of operation, each with blockade of pancreatic duct by N-octyl-α-cyanoacrylate, were performed in 27 dogs divided into 3 groups: (1) removal of the right two thirds of the pancreas and the left one third left in situ (n = 4), (2) total pancreatectomy and intraperitoneal autotransplantation of the left limb (n = 16), (3) total pancreatectomy and intraperitoneal allotransplantation of the left limb (n = 7). The purpose of injection of cyanoacrylate glue into the pancreatic duct is to suppress the exocrine function of the organ, thereby transforming its dual function of external and internal secretion into purely endocrinous one. After obliteration the animals remained normoglycemic on the first postoperative day, and after autotransplantation the longest observation period was 6 months with normoglycemia. Allografted animals showed an average period for normoglycemia of 19 ± 16 days (5–46 days) and survived for 36.7 ± 17.6 days (13–62 days). Hyperglycemia has been considered as a sign of pancreatic allorejection, but it could be prevented by conventional immunosuppressive therapy.

The results obtained in detecting circulating immune complex (CIC) and HBsAg-CIC dissociation in children with hepatitis B glomerulonephritis (GN) by using simplified methods of polyethylene glycol precipitation (PEG) and PEG-trypsin were reported in this paper. As the difference of results in detecting CIC was not significant in different HBsAg (+) patient groups, this method seems not to be specific to the diagnosis and differential diagnosis of hepatitis B GN. However, HBsAg-CIC dissociation was positive in most cases of active hepatitis B GN. Its positive rate reached as high as 90.5%, while in remission as low as 23 %. So we come to the conclusion that the dissociation method of specific antigen is not only a valuable laboratory parameter for diagnosing hepatitis B GN, but also is useful in judging whether this disorder is in active stage or not.

Im Zeitraum von 20 Jahren (1955 bis 1975) wurden 1480 Fälle von Zervixkarzinom bestrahlt. Es überlebten 987 von 1480 (66,7%) 5 Jahre. Im Stadium I wurde eine 5-Jahres-Überlebensrate von 86,3%, im Stadium II eine solche von 73,4% und im Stadium II von 56% erreicht. Die Prognose bei Patientinnen mit Adenokarzinom und in Assoziation mit Gravidität wird analysiert. Es ist selbstverständlich, daß frühe Erkennung der Erkrankung und eine weitgehende Individualisierung der Behandlung für jede Patientin wichtige Maßnahmen zur Verhütung des Therapieversagens sind.

An den histologischen Präparaten von 285 Patientinnen, die in dem Zeitraum von 1968–1975 an einem Plattenepithelkarzinom der Zervix erkrankt waren, wurden der Zelltyp, die Wachstumsform, die Stromareaktion und die peritumorale Fibrinreaktion untersucht und die Ergebnisse mit der 5-Jahres-Uberlebensrate nach Strahlentherapie verglichen. Sie ist am günstigsten beim großzelligen Typ, bei papillärer Wachstumsform und bei starker Zellinfiltration; eine deutliche peritumorale Fibrinreaktion scheint ebenfalls zum Heilerfolg beizutragen. Um die Besprechung der prognostischen Bedeutung einzelner histologischer Kriterien zu erleichtern, haben wir Punkte zur Bewertung der Malignität vorgeschlagen.

Wuchereria bancrofti, which parasitizes in lymphatic system of human body, induces chyluria. Formerly, the pathogenesis of chyluria was explained to be due to obstruction of thoracic duct. This assay, through reviewing of literature and experiences in operation in renal pedicle, has pointed out a new concept of pathogenesis of chyluria— the retroperitoneal lymphangiectasis.

Clinical experience has demonstrated that rhomotoxin, isolated from the fruits of Rhododendron molle G. Don, has antihypertensive and antiarrhythmic effects. In the present work, its direct actions on cat papillary muscle were as follows:

It is suggested that the above effects of rhomotoxin might be due to the change in resting potential of the myocardial cell as a result of altered transmembrane sodium movement.

Ein Einschrittrosettentest zum Nachweis der T-, Ty- und Tu-Lymphozyten in nicht-fraktionierten Lymphozytensuspensionen wird beschrieben, und die erhaltenen Werte wurden mit denen des Zweischrittrosettentestes verglichen. Es ergaben sich keine Unterschiede zwischen den mit den beiden Testverfahren ermittelten Untersuchungswerten der T-, Tγ- und Tμ-Zellen bei 51 gesunden Spendern. Die Bestimmung der T-, Tγ- und Tμ-Zellenwerte mit dem Einschrittrosettentest bei 104 gesunden Spendern wurde ähnlich wie von anderen Autoren angegeben durchgeführt. Hierbei wurde auch nachgewiesen, daß die Inkubationsdauer der Zellsuspensionen bei 4 °C und die Proportion zwischen Schaferythrozyten und Fluoreszeinisothiozyanat-markierten Rindererythrozyten (FITC-BRBC) die prozentuale Verteilung der T-, Tγ- und Tμ-Zellen beeinflussen können.

Peripheral erythrocyte rosette-forming cells (ERFC), Tγ cell and Tμ cell counts were studied in 141 children with different types of viral hepatitis and in 65 healthy children as control. The results showed variations not only in total number of ERFC, but also in Tγ cells and Tμ cells in different types of viral hepatitis. It was also found that determination of Tγ cell percentage may be of value in diagnosing the condition of the diseases, and determination of Tγ cell and Tγ/Tμ ratio may be of value in estimating the prognosis. The possible mechanism of variations in ERFC, Tγ cells and Tμ cells is discussed.

Concentrations of K⁺, Na⁺ and Mg⁺⁺ were measured in plasma (K⁺_e, Na⁺_e, Mg⁺⁺_e) and in erythrocytes (K⁺_i, Na⁺_i, Mg⁺⁺_i) in patients with digitalis toxicity before and after administration of Mg. K⁺ concentration in 24-hour urine was also measured. 70 persons were divided into 5 groups: (1) 11 normal persons as controls; (2) 19 patients with congestive heart failure, in whom Mg⁺⁺_i and Mg⁺⁺_e concentrations were found to be lower than that of the control group; (3) 16 patients with digitalis toxicity treated by Mg⁺⁺, whose K⁺_i concentration increased much quicker, and Na⁺_i and Na⁺_i/K⁺_i decreased remarkably in comparison to non-Mg treatment group; (4) 12 patients with digitalis toxicity not treated by Mg⁺⁺: in these the above-mentioned changes were not significant; (5) 12 patients with arrhythmia of other causes treated by Mg⁺⁺: whose K⁺_i also increased significantly on the 3rd day after treatment.

K⁺ concentration in 24-hour urine was much lower in Mg treatment group than in non-Mg treatment group.

Besides, acute digitalis toxicity was observed in experimental dogs. The concentration of K⁺_i recovered much quicker in Mg treatment group than in control group.

These findings indicate that hypomagnesemia may induce digitalis toxicity. In this paper the possible mechanism of the therapeutic effect of Mg in the treatment of digitalis toxicity is discussed.

Levels of thyroid hormones (T₃,T₄) in serum and cyclic adenosine 3′, 5′-monophosphate (cAMP) and cyclic guanosine 3′, 5′-monophosphate (cGMP) in plasma were successively determined in 77 patients with hyperthyroidism before and 1, 2, 3, 6 months after¹³¹iodine (¹³¹I) treatment. Before treatment, the levels of total serum T₃, T₄ and plasma cAMP of all of the patients were higher than normal, while the level of plasma cGMP was lower than normal (P<0.0l). The patients were divided into 3 groups: A, B, C, according to the clinical features and serum levels of T₃, T₄ 3–6 months after treatment. Group A (18 patients) clinically showed no improvement, T₃, T₄ still remained higher than normal and cAMP, cGMP revealed no significant change in comparison with the pretreatment state. Group B (45 patients) clinically showed marked improvement, their thyroid toxic symptoms practically subsided, T₃, T₄ gradually turned to normal and concentration of cAMP and cGMP subsequently reached normal level. Group C (14 patients) presented temporary hypothyroidic features; their level of T₃, T₄ fell below the normal range, while the concentration of plasma cAMP and cGMP approached the level contrary to the state before treatment. Since the change of T₃ and T₄ occurred synchronously, the question of whether T₃ or T₄ exerted an influence on plasma cyclic nucleotides concentration and the interrelationship between thyroid hormones and cyclic nucleotides as well as the significance of plasma cAMP and cGMP in pathogenesis and therapy of hyperthyroidism remains to be further elucidated.

This study was designed to investigate the levels of testis tissue cyclic nucleotides and plasma testosterone in testis-irradiated rats with saturation analysis 1–52 days after 676 rad and 7 days after 290–1930 rad. It was found that ionizing radiation of a given dose scale did not affect significantly the excretion of testosterone. An initial rise of cyclic adenosine monophosphate (cAMP) was probably associated with an increase of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) excretion and a decrease of cAMP in the later stage was possibly due to the depletion of the germ cells, following irradiation less than 965 rad. The reduction of cAMP after 1930 rad was probably related to direct inhibition of the larger dose of cAMP production. These results suggest that the levels of cAMP after irradiation can reflect the degree of testis radiation injury. In addition, it was also found that ionizing radiation failed to change the testis cyclic guanosine monophosphate (cGMP) levels, suggesting the presence in testis of only a “one-way” regulation carried out by cAMP.