Duct-obliterated canine pancreatic segmental transplantation

Abstract

In this study 3 various kinds of operation, each with blockade of pancreatic duct by N-octyl-α-cyanoacrylate, were performed in 27 dogs divided into 3 groups: (1) removal of the right two thirds of the pancreas and the left one third left in situ (n = 4), (2) total pancreatectomy and intraperitoneal autotransplantation of the left limb (n = 16), (3) total pancreatectomy and intraperitoneal allotransplantation of the left limb (n = 7). The purpose of injection of cyanoacrylate glue into the pancreatic duct is to suppress the exocrine function of the organ, thereby transforming its dual function of external and internal secretion into purely endocrinous one. After obliteration the animals remained normoglycemic on the first postoperative day, and after autotransplantation the longest observation period was 6 months with normoglycemia. Allografted animals showed an average period for normoglycemia of 19 ± 16 days (5–46 days) and survived for 36.7 ± 17.6 days (13–62 days). Hyperglycemia has been considered as a sign of pancreatic allorejection, but it could be prevented by conventional immunosuppressive therapy.

Keywords

duct-obliterated pancreatic segmental transplantation / N-octyl-α-cyanoacrylate

References

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