Investigation of Tγ cells and Tμ cells in peripheral blood of children with different types of viral hepatitis

Abstract

Peripheral erythrocyte rosette-forming cells (ERFC), Tγ cell and Tμ cell counts were studied in 141 children with different types of viral hepatitis and in 65 healthy children as control. The results showed variations not only in total number of ERFC, but also in Tγ cells and Tμ cells in different types of viral hepatitis. It was also found that determination of Tγ cell percentage may be of value in diagnosing the condition of the diseases, and determination of Tγ cell and Tγ/Tμ ratio may be of value in estimating the prognosis. The possible mechanism of variations in ERFC, Tγ cells and Tμ cells is discussed.

Keywords

Tγ cell / Tμ cell / viral hepatitis

References

[1] GuptaS, et al. . Subpopulation of human T lymphocytes: II. Distribution and quantilation in peripheral blood, cord blood, tonsils, bone marrow, thymus, lymphonodes, and spleen. Cell Immunol, 1978, 36263-263

[2] T-cell subsets Tγ, Tμ 20: 1040, 1979

[3] CoovadiaHM, et al. . Suppressor cells assayed by three different methods in patients with chronic active hepatitis and systemic lupus erythematosus. Clin Immunol Immunopathol, 1981, 18268-268

[4] VyasGN, et al. . Viral hepatitis, 1978, Philadelphia, Franklin Institute Press: 245-266

[5] MillerDJ, et al. . Identification of lymphocytes in percutaneous liver biopsy cores: Different T:B cell ratio in HBsAgpositive and -negative hepatitis. Gastroenterology, 1977, 721199-1199

[6] ChisariFV, et al. . Mechanisms responsible for detective human T-lymphocytes sheep erythrocyte-rosette function associated with hepatitis B virus infection. J Clin Invest, 1976, 571227-1227

[7] PichlerWJ. Bedeutung von Fc-IgG und Fc-IgM Rezeptoren auf menschlichen T-Lymphozyten. Klin Wochenschr, 1981, 5999-99

[8] ShawS, et al. . Fc receptors on human Tlymphocyte: III. Characterization of subpopulations involved in cell-mediated lympholysis and antibody-dependent cellular cytotoxicity. J Immunol, 1979, 122599-599

[9] GuptaS, et al. . Spontaneous and antibody-dependent cell-mediated cytotoxicity by human T cell subpopulations. Proc Natl Acad Sci USA, 1978, 755137-5137