Detection of HBsAg from circulating immune complex: Clinical significance in diagnosis of hepatitis B glomerulonephritis in children

Abstract

The results obtained in detecting circulating immune complex (CIC) and HBsAg-CIC dissociation in children with hepatitis B glomerulonephritis (GN) by using simplified methods of polyethylene glycol precipitation (PEG) and PEG-trypsin were reported in this paper. As the difference of results in detecting CIC was not significant in different HBsAg (+) patient groups, this method seems not to be specific to the diagnosis and differential diagnosis of hepatitis B GN. However, HBsAg-CIC dissociation was positive in most cases of active hepatitis B GN. Its positive rate reached as high as 90.5%, while in remission as low as 23 %. So we come to the conclusion that the dissociation method of specific antigen is not only a valuable laboratory parameter for diagnosing hepatitis B GN, but also is useful in judging whether this disorder is in active stage or not.

Keywords

circulating immune complex / HBsAg-CIC dissociation / hepatitis B glomerulonephritis

References

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