AXL belongs to the TAM receptor tyrosine kinase family. Relying on binding its high‐affinity ligand—growth arrest‐specific protein 6 (Gas6)—AXL plays an important role in tumor initiation and progression. Traditional Chinese Medicine (TCM) has been clinically used in tumor treatment for a long time, and remarkable therapeutic efficacy has been achieved. Recent studies pointed out that some natural products derived from TCM could inhibit tumor growth by targeting AXL. The potential antitumor mechanisms of natural products targeting AXL still need to be understood. In this review, we discussed the relationship between the AXL axis and tumor malignant phenotype, including migration, invasion, drug resistance, and immunosuppression. The effects and mechanisms of natural products on targeting AXL in tumors also have been systematically summarized.
Diabetic foot is a chronic refractory wound associated with high disability and mortality rates, which not only threatens the health of patients but also imposes a heavy medical burden on patients and their families. Chinese medicine has been widely used to treat diabetic foot. As a traditional Chinese medicine, ulcer oil possesses a number of beneficial properties. It can clear heat and toxins, activate blood and tissue regeneration, reduce swelling, and alleviate pain. Moreover, ulcer oil can regulate inflammation, promote capillary neoangiogenesis, and enhance granulation growth and epithelial crawling. Furthermore, it can maintain a moist environment within the wound. It is hypothesized that ulcer oil can accelerate the healing of diabetic foot ulcers via a combination of these effects. These observations indicate that ulcer oil has the potential to prevent diabetic foot ulcers and treat high‐risk diabetic foot conditions. In this article, we provide a comprehensive analysis of the utilization of ulcer oil in the management of diabetic foot conditions. Its indications, contraindications, and other pertinent aspects are described to establish a foundation for the clinical application of this therapeutic modality.
Psoriasis is a chronic, inflammatory skin condition characterized by its recurrent nature, often accompanied by various systemic comorbidities. It may not fully satisfy the precise diagnostic and therapeutic demands for psoriasis by the theory of syndrome differentiation and treatment of traditional Chinese medicine (TCM). Guided by Academician Tong Xiaolin's “theory of state‐target differentiation and treatment,” psoriasis can be divided into “early stage, middle stage, and late stage,” and “constraint state, excess state, and deficiency state.” Defining the target prescription and targeted Chinese materia medcia of psoriasis in each stage and establishing the system of state‐target differentiation and treatment of psoriasis could provide a new model for clinical diagnosis and treatment.
