The deconstruction of the psoriasis system based on the theory of state‐target differentiation and treatment

Abstract

Psoriasis is a chronic, inflammatory skin condition characterized by its recurrent nature, often accompanied by various systemic comorbidities. It may not fully satisfy the precise diagnostic and therapeutic demands for psoriasis by the theory of syndrome differentiation and treatment of traditional Chinese medicine (TCM). Guided by Academician Tong Xiaolin's “theory of state‐target differentiation and treatment,” psoriasis can be divided into “early stage, middle stage, and late stage,” and “constraint state, excess state, and deficiency state.” Defining the target prescription and targeted Chinese materia medcia of psoriasis in each stage and establishing the system of state‐target differentiation and treatment of psoriasis could provide a new model for clinical diagnosis and treatment.

Keywords

diagnosis and treatment system / psoriasis / stage recognition / state-target differentiation and treatment

References

[1] Griffiths CEM, Armstrong AW, Gudjonsson JE, Barker JNWN. Psoriasis. Lancet. 2021; 397 (10281): 1301- 1315.

[2] World Health Organization. Global Report on Psoriasis. World Health Organization; 2016.

[3] Parisi R, Iskandar IYK, Kontopantelis E, Augustin M, Griffiths CEM, Ashcroft DM. National, regional, and worldwide epidemiology of psoriasis: systematic analysis and modelling study. BMJ. 2020; 369: m1590.

[4] Li H, Hu L, Zheng Y. Epidemiological burden analysis of psoriasis in China based on global burden of disease (GBD) big data. Chin J Dermatovenereol. 2021; 4: 386- 392 (in Chinese).

[5] GBD 2019 IMID Collaborators. Global, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the global burden of disease study 2019 [J]. EClinicalMedicine. 2023; 64: 102193.

[6] Jia H, Shen C, Liu X. Thoughts and prospects of basic research on traditional Chinese medicine for psoriasis. Chin J Dermatovenereol. 2024; 7: 715- 723 (in Chinese).

[7] Zhang L, Xue C, Zhou L. An analysis of the modern integrative medicine model of integrative medicine from target to state. J Tradit Chin Med. 2023; 22: 2269- 2274 (in Chinese).

[8] Tong X. Target medicine: the future development of traditional Chinese medicine. Chin J Integr Med. 2021; 1: 16- 18 (in Chinese).

[9] He L, Song P, Zhao L. State-target pattern differentiation: the historical selection of traditional Chinese medicine from macroscopic to precise. Liaoning J Tradit Chin Med. 2020; 01: 1- 4 (in Chinese).

[10] Tong X, He L, Zhao L. On the clinical differentiation and treatment strategy of "state target causality" in traditional Chinese medicine. J Tradit Chin Med. 2015; 17: 1441- 1444 (in Chinese).

[11] Lin J, Tian J, Fang X, et al. Guiding modern traditional Chinese medicine research using the theory of state-target differentiation and treatment—maintaining the validity of traditional Chinese medicine and creating new medical science. Adv Chin Med. 2024; 1 (1): 3- 12 (in Chinese).

[12] Xu K, Yao C, Li M. Discussion on the medication strategy of type 2 diabetes based on "state target causality. China J Tradit. 2021; 9: 5372- 5376 (in Chinese).

[13] Yang Y, Wei X, Wang T. Tong Xiaolin's experience in the identification and treatment of "three stages and six states" hypertension. China J. Tradit. 2020; 6: 2949- 2953 (in Chinese).

[14] Gou X, Yang Y, Zhang W. Target identification and treatment strategies for female obesity. China J Tradit. 2023; 9: 4245- 4248 (in Chinese).

RIGHTS & PERMISSIONS

2025 The Author(s). Advanced Chinese Medicine published by John Wiley & Sons Australia, Ltd on behalf of Higher Education Press.