
Clinical application specifications for ulcer oil in the treatment of diabetic foot ulcers
Jie Wang, Quan Yuan, Yueqi Wang, Jiajun Qiao, Yunru Chen, Chunli Tan, Zhongyuan Xia, Shouyao Liu
Adv. Chi. Med ›› 2024, Vol. 1 ›› Issue (4) : 190-199.
Clinical application specifications for ulcer oil in the treatment of diabetic foot ulcers
Diabetic foot is a chronic refractory wound associated with high disability and mortality rates, which not only threatens the health of patients but also imposes a heavy medical burden on patients and their families. Chinese medicine has been widely used to treat diabetic foot. As a traditional Chinese medicine, ulcer oil possesses a number of beneficial properties. It can clear heat and toxins, activate blood and tissue regeneration, reduce swelling, and alleviate pain. Moreover, ulcer oil can regulate inflammation, promote capillary neoangiogenesis, and enhance granulation growth and epithelial crawling. Furthermore, it can maintain a moist environment within the wound. It is hypothesized that ulcer oil can accelerate the healing of diabetic foot ulcers via a combination of these effects. These observations indicate that ulcer oil has the potential to prevent diabetic foot ulcers and treat high‐risk diabetic foot conditions. In this article, we provide a comprehensive analysis of the utilization of ulcer oil in the management of diabetic foot conditions. Its indications, contraindications, and other pertinent aspects are described to establish a foundation for the clinical application of this therapeutic modality.
diabetic foot / indications / specification / ulcer oil
[1] |
Guo L , Xiao X . Guideline for the management of diabetes mellitus in the elderly in China (2024 edition). Aging Med (Milton). 2024; 7 (1): 5- 51.
CrossRef
Google scholar
|
[2] |
Magliano DJ , Boyko EJDA . IDF Diabetes ATLAS. International Diabetes Federation. 2021.
|
[3] |
Van Netten JJ , Bus SA , Apelqvist J , et al. Definitions and criteria for diabetes-related foot disease (IWGDF 2023 update). Diabetes Metab Res Rev. 2024; 40 (3): e3654.
CrossRef
Google scholar
|
[4] |
McDermott K , Fang M , Boulton A , Selvin E , Hicks CW . Etiology, epidemiology, and disparities in the burden of diabetic foot ulcers. Diabetes Care. 2023; 46 (1): 209- 221.
CrossRef
Google scholar
|
[5] |
Wang A , Lv G , Cheng X , et al. Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease (2020 edition). Burns Trauma. 2020; 8: tkaa017.
CrossRef
Google scholar
|
[6] |
Lo ZJ , Surendra NK , Saxena A , Car J . Clinical and economic burden of diabetic foot ulcers: a 5-year longitudinal multi-ethnic cohort study from the tropics. Int Wound J. 2021; 18 (3): 375- 386.
CrossRef
Google scholar
|
[7] |
Mariadoss A , Sivakumar AS , Lee CH , Kim SJ . Diabetes mellitus and diabetic foot ulcer: etiology, biochemical and molecular based treatment strategies via gene and nanotherapy. Biomed Pharmacother. 2022; 151: 113134.
CrossRef
Google scholar
|
[8] |
Wang X , Yuan CX , Xu B , Yu Z . Diabetic foot ulcers: classification, risk factors and management. World J Diabetes. 2022; 13 (12): 1049- 1065.
CrossRef
Google scholar
|
[9] |
Marso SP , Hiatt WR . Peripheral arterial disease in patients with diabetes. J Am Coll Cardiol. 2006; 47 (5): 921- 929.
CrossRef
Google scholar
|
[10] |
Liao F , An R , Pu F , Burns S , Shen S , Jan YK . Effect of exercise on risk factors of diabetic foot ulcers: a systematic review and meta-analysis. Am J Phys Med Rehabil. 2019; 98 (2): 103- 116.
CrossRef
Google scholar
|
[11] |
Wang N , Yang BH , Wang G , et al. A meta-analysis of the relationship between foot local characteristics and major lower extremity amputation in diabetic foot patients. J Cell Biochem. 2019; 120 (6): 9091- 9096.
CrossRef
Google scholar
|
[12] |
Zhang X , Ran X , Xu Z , et al. Epidemiological characteristics of lower extremity arterial disease in Chinese diabetes patients at high risk: a prospective, multicenter, cross-sectional study. J Diabet Complicat. 2018; 32 (2): 150- 156.
CrossRef
Google scholar
|
[13] |
Lipsky BA . Diabetic foot infections: current treatment and delaying the ‘post-antibiotic era’. Diabetes Metab Res Rev. 2016; 32 Suppl 1: 246- 253.
CrossRef
Google scholar
|
[14] |
Bellomo TR , Lee S , McCarthy M , et al. Management of the diabetic foot. Semin Vasc Surg. 2022; 35 (2): 219- 227.
CrossRef
Google scholar
|
[15] |
Perez-Favila A , Martinez-Fierro ML , Rodriguez-Lazalde JG , et al. Current therapeutic strategies in diabetic foot ulcers. Medicina (Kaunas). 2019; 55 (11): 714.
CrossRef
Google scholar
|
[16] |
Khan MS , Azam M , Khan MN , et al. Identification of contributing factors, microorganisms and antimicrobial resistance involved in the complication of diabetic foot ulcer treatment. Microb Pathog. 2023; 184: 106363.
CrossRef
Google scholar
|
[17] |
Xu Z , Ran X . Diabetic foot care in China: challenges and strategy. Lancet Diabetes Endocrinol. 2016; 4 (4): 297- 298.
CrossRef
Google scholar
|
[18] |
Zhou X , Guo Y , Yang K , Liu P , Wang J . The signaling pathways of traditional Chinese medicine in promoting diabetic wound healing. J Ethnopharmacol. 2022; 282: 114662.
CrossRef
Google scholar
|
[19] |
Zhou Z , Deng T , Tao M , et al. Snail-inspired AFG/GelMA hydrogel accelerates diabetic wound healing via inflammatory cytokines suppression and macrophage polarization. Biomaterials. 2023; 299: 122141.
CrossRef
Google scholar
|
[20] |
Han G , Ceilley R . Chronic wound healing: a review of current management and treatments. Adv Ther. 2017; 34 (3): 599- 610.
CrossRef
Google scholar
|
[21] |
Liu F , Li Y , Guo X , Liu RC , Zhang HY , Li Z . Advances in traditional Chinese medicine as adjuvant therapy for diabetic foot. World J Diabetes. 2022; 13 (10): 851- 860.
CrossRef
Google scholar
|
[22] |
Wang J , Wang Y , Huang R , et al. Uncovering the pharmacological mechanisms of Zhihu ointment against diabetic ulcer by integrating network analysis and experimental evaluation in vivo and in vitro. Front Pharmacol. 2022; 13: 1027677.
CrossRef
Google scholar
|
[23] |
Jia H , Yang B , Li Y , et al. Chinese medicine ulcer oil promotes the healing of diabetic foot ulcers. J Int Med Res. 2018; 46 (7): 2679- 2686.
CrossRef
Google scholar
|
[24] |
Fei J , Ling YM , Zeng MJ , Zhang KW . Shixiang plaster, a traditional Chinese medicine, promotes healing in a rat model of diabetic ulcer through the receptor for advanced glycation end products (RAGE)/Nuclear factor kappa B (NF-kappaB) and vascular endothelial growth factor (VEGF)/Vascular cell adhesion molecule-1 (VCAM-1)/Endothelial nitric oxide synthase (eNOS) signaling pathways. Med Sci Mon Int Med J Exp Clin Res. 2019; 25: 9446- 9457.
CrossRef
Google scholar
|
[25] |
Zhang H , Nie X , Shi X , et al. Regulatory mechanisms of the wnt/beta-catenin pathway in diabetic cutaneous ulcers. Front Pharmacol. 2018, 9: 1114.
CrossRef
Google scholar
|
[26] |
Cao Y , Xu L , Yang X , et al. The potential role of cycloastragenol in promoting diabetic wound repair in vitro. BioMed Res Int. 2019; 18: 7023950.
CrossRef
Google scholar
|
[27] |
Chen PY , Qin L , Li G , et al. Endothelial TGF-beta signalling drives vascular inflammation and atherosclerosis. Nat Metab. 2019; 1 (9): 912- 926.
CrossRef
Google scholar
|
[28] |
Sun Z , Liu C , Chen Q , et al. Effects of Xiangpi Shengji ointment on EMT in wound tissues of diabetic ulcer rats. Shaanxi J Tradit Chin Med. 2022; 43 (12): 1664- 1668.
|
[29] |
Zhuo S , Qiao X , Chen J , et al. Mechanism of Fufang Yuyang powder on diabetic skin ulcers healing. Chin J Exp Tradit Med Formulae. 2015; 21 (04): 115- 119.
|
[30] |
Zhang C , Chen L , Zhao W , et al. Danhuang powder promotes the wound healing of diabetic foot ulcer through transforming growth factor-β1/Smad3 signaling pathway in rats. Chin J Clin Pharmacol Therapeut. 2020; 36 (21): 3473- 3476.
|
[31] |
Guo J , Hu Z , Yan F , et al. Angelica dahurica promoted angiogenesis and accelerated wound healing in db/db mice via the HIF-1α/PDGF-β signaling pathway. Free Radic Biol Med. 2020; 160: 447- 457.
CrossRef
Google scholar
|
[32] |
Wang J , Wang L , Zhou H , et al. The isolation, structural features and biological activities of polysaccharide from Ligusticum chuanxiong: a review. Carbohydr Polym. 2022; 285: 118971.
CrossRef
Google scholar
|
[33] |
Cao YJ , Pu ZJ , Tang YP , et al. Advances in bio-active constituents, pharmacology and clinical applications of rhubarb. Chin Med. 2017; 12 (1): 36.
CrossRef
Google scholar
|
[34] |
Wang B , Zhang X , Zhao Y , et al. Observations on the effect of BaWeiGuWeiGao under the guidance of the four sides theory in the treatment of diabetic foot ulcer of damp-heat-toxic type. Shandong Med J. 2019; 59 (26): 68- 70.
|
[35] |
Lou P . Clinical Efficacy of Ulcer Oil in Promoting the Healing of Diabetic Foot Ulcers. BUCM. 2023: 1- 9.
|
[36] |
Lee JC , Kandula S , Sherber NS . Beyond wet-to-dry: a rational approach to treating chronic wounds. Eplasty. 2009; 9: e14.
|
[37] |
Sim P , Strudwick XL , Song Y , Cowin AJ , Garg S . Influence of acidic pH on wound healing in vivo: a novel perspective for wound treatment. Int J Mol Sci. 2022; 23 (21). 13655.
CrossRef
Google scholar
|
[38] |
Dilixiati K , Chen Z , Liu X . Clinical study of vacuum sealing drainage combined with autologous skin grafting under oxygen supply in the treatment of refractory diabetic foot ulcer. Chin J Inj Repair Wound Healing, Electron. 2022; 17 (01): 25- 31.
|
[39] |
Wang Y , Xu X , Lu P . Clinical efficacy of licorice oil in treating wounds after diabetic foot skin grafting. Mod Chin Med. 2024; 26 (07): 1260- 1264.
|
[40] |
Cardinal M , Eisenbud DE , Armstrong DG , et al. Serial surgical debridement: a retrospective study on clinical outcomes in chronic lower extremity wounds. Wound Repair Regen. 2009; 17 (3): 306- 311.
CrossRef
Google scholar
|
[41] |
Barwick A , Tessier J , Mirow J , De Jonge XJ , Chuter V . Computed tomography derived bone density measurement in the diabetic foot. J Foot Ankle Res. 2017; 10 (1): 11.
CrossRef
Google scholar
|
[42] |
Yang L , Rong GC , Wu QN . Diabetic foot ulcer: challenges and future. World J Diabetes. 2022; 13 (12): 1014- 1034.
CrossRef
Google scholar
|
[43] |
Ji S , Liu X , Huang J , et al. Consensus on the application of negative pressure wound therapy of diabetic foot wounds. Burns Trauma. 2021; 9: tkab018.
CrossRef
Google scholar
|
[44] |
Li J , Wang HY , Yang YF , Wang A , Shi Y , Cui T . Efficacy of the combination of Chinese herbal medicine and negative pressure wound therapy in the treatment of patients with diabetic foot ulcer: a meta-analysis. Int Wound J. 2024; 21 (4): e14536.
CrossRef
Google scholar
|
[45] |
Marti-Carvajal AJ , Gluud C , Nicola S , et al. Growth factors for treating diabetic foot ulcers. Cochrane Database Syst Rev. 2015; 2015 (10): D8548.
CrossRef
Google scholar
|
[46] |
Liu Y , Liu Y , Deng J , Li W , Nie X . Fibroblast growth factor in diabetic foot ulcer: progress and therapeutic prospects. Front Endocrinol. 2021; 12: 744868.
CrossRef
Google scholar
|
[47] |
Li P , Chen S , Gao X , et al. Application of hospital-community-family care model in patients with diabetic foot who underwent transverse tibial osteotomy. J. Mod. Med. Health. 2024; 40 (09): 1584- 1588.
|
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