Clinical application specifications for ulcer oil in the treatment of diabetic foot ulcers

Jie Wang , Quan Yuan , Yueqi Wang , Jiajun Qiao , Yunru Chen , Chunli Tan , Zhongyuan Xia , Shouyao Liu

Adv. Chi. Med ›› 2024, Vol. 1 ›› Issue (4) : 190 -199.

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Adv. Chi. Med ›› 2024, Vol. 1 ›› Issue (4) :190 -199. DOI: 10.1002/acm4.30
RESEARCH ARTICLE

Clinical application specifications for ulcer oil in the treatment of diabetic foot ulcers

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Abstract

Diabetic foot is a chronic refractory wound associated with high disability and mortality rates, which not only threatens the health of patients but also imposes a heavy medical burden on patients and their families. Chinese medicine has been widely used to treat diabetic foot. As a traditional Chinese medicine, ulcer oil possesses a number of beneficial properties. It can clear heat and toxins, activate blood and tissue regeneration, reduce swelling, and alleviate pain. Moreover, ulcer oil can regulate inflammation, promote capillary neoangiogenesis, and enhance granulation growth and epithelial crawling. Furthermore, it can maintain a moist environment within the wound. It is hypothesized that ulcer oil can accelerate the healing of diabetic foot ulcers via a combination of these effects. These observations indicate that ulcer oil has the potential to prevent diabetic foot ulcers and treat high‐risk diabetic foot conditions. In this article, we provide a comprehensive analysis of the utilization of ulcer oil in the management of diabetic foot conditions. Its indications, contraindications, and other pertinent aspects are described to establish a foundation for the clinical application of this therapeutic modality.

Keywords

diabetic foot / indications / specification / ulcer oil

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Jie Wang, Quan Yuan, Yueqi Wang, Jiajun Qiao, Yunru Chen, Chunli Tan, Zhongyuan Xia, Shouyao Liu. Clinical application specifications for ulcer oil in the treatment of diabetic foot ulcers. Adv. Chi. Med, 2024, 1(4): 190-199 DOI:10.1002/acm4.30

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References

[1]

Guo L , Xiao X . Guideline for the management of diabetes mellitus in the elderly in China (2024 edition). Aging Med (Milton). 2024; 7 (1): 5- 51.

[2]

Magliano DJ , Boyko EJDA . IDF Diabetes ATLAS. International Diabetes Federation. 2021.

[3]

Van Netten JJ , Bus SA , Apelqvist J , et al. Definitions and criteria for diabetes-related foot disease (IWGDF 2023 update). Diabetes Metab Res Rev. 2024; 40 (3): e3654.

[4]

McDermott K , Fang M , Boulton A , Selvin E , Hicks CW . Etiology, epidemiology, and disparities in the burden of diabetic foot ulcers. Diabetes Care. 2023; 46 (1): 209- 221.

[5]

Wang A , Lv G , Cheng X , et al. Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease (2020 edition). Burns Trauma. 2020; 8: tkaa017.

[6]

Lo ZJ , Surendra NK , Saxena A , Car J . Clinical and economic burden of diabetic foot ulcers: a 5-year longitudinal multi-ethnic cohort study from the tropics. Int Wound J. 2021; 18 (3): 375- 386.

[7]

Mariadoss A , Sivakumar AS , Lee CH , Kim SJ . Diabetes mellitus and diabetic foot ulcer: etiology, biochemical and molecular based treatment strategies via gene and nanotherapy. Biomed Pharmacother. 2022; 151: 113134.

[8]

Wang X , Yuan CX , Xu B , Yu Z . Diabetic foot ulcers: classification, risk factors and management. World J Diabetes. 2022; 13 (12): 1049- 1065.

[9]

Marso SP , Hiatt WR . Peripheral arterial disease in patients with diabetes. J Am Coll Cardiol. 2006; 47 (5): 921- 929.

[10]

Liao F , An R , Pu F , Burns S , Shen S , Jan YK . Effect of exercise on risk factors of diabetic foot ulcers: a systematic review and meta-analysis. Am J Phys Med Rehabil. 2019; 98 (2): 103- 116.

[11]

Wang N , Yang BH , Wang G , et al. A meta-analysis of the relationship between foot local characteristics and major lower extremity amputation in diabetic foot patients. J Cell Biochem. 2019; 120 (6): 9091- 9096.

[12]

Zhang X , Ran X , Xu Z , et al. Epidemiological characteristics of lower extremity arterial disease in Chinese diabetes patients at high risk: a prospective, multicenter, cross-sectional study. J Diabet Complicat. 2018; 32 (2): 150- 156.

[13]

Lipsky BA . Diabetic foot infections: current treatment and delaying the ‘post-antibiotic era’. Diabetes Metab Res Rev. 2016; 32 Suppl 1: 246- 253.

[14]

Bellomo TR , Lee S , McCarthy M , et al. Management of the diabetic foot. Semin Vasc Surg. 2022; 35 (2): 219- 227.

[15]

Perez-Favila A , Martinez-Fierro ML , Rodriguez-Lazalde JG , et al. Current therapeutic strategies in diabetic foot ulcers. Medicina (Kaunas). 2019; 55 (11): 714.

[16]

Khan MS , Azam M , Khan MN , et al. Identification of contributing factors, microorganisms and antimicrobial resistance involved in the complication of diabetic foot ulcer treatment. Microb Pathog. 2023; 184: 106363.

[17]

Xu Z , Ran X . Diabetic foot care in China: challenges and strategy. Lancet Diabetes Endocrinol. 2016; 4 (4): 297- 298.

[18]

Zhou X , Guo Y , Yang K , Liu P , Wang J . The signaling pathways of traditional Chinese medicine in promoting diabetic wound healing. J Ethnopharmacol. 2022; 282: 114662.

[19]

Zhou Z , Deng T , Tao M , et al. Snail-inspired AFG/GelMA hydrogel accelerates diabetic wound healing via inflammatory cytokines suppression and macrophage polarization. Biomaterials. 2023; 299: 122141.

[20]

Han G , Ceilley R . Chronic wound healing: a review of current management and treatments. Adv Ther. 2017; 34 (3): 599- 610.

[21]

Liu F , Li Y , Guo X , Liu RC , Zhang HY , Li Z . Advances in traditional Chinese medicine as adjuvant therapy for diabetic foot. World J Diabetes. 2022; 13 (10): 851- 860.

[22]

Wang J , Wang Y , Huang R , et al. Uncovering the pharmacological mechanisms of Zhihu ointment against diabetic ulcer by integrating network analysis and experimental evaluation in vivo and in vitro. Front Pharmacol. 2022; 13: 1027677.

[23]

Jia H , Yang B , Li Y , et al. Chinese medicine ulcer oil promotes the healing of diabetic foot ulcers. J Int Med Res. 2018; 46 (7): 2679- 2686.

[24]

Fei J , Ling YM , Zeng MJ , Zhang KW . Shixiang plaster, a traditional Chinese medicine, promotes healing in a rat model of diabetic ulcer through the receptor for advanced glycation end products (RAGE)/Nuclear factor kappa B (NF-kappaB) and vascular endothelial growth factor (VEGF)/Vascular cell adhesion molecule-1 (VCAM-1)/Endothelial nitric oxide synthase (eNOS) signaling pathways. Med Sci Mon Int Med J Exp Clin Res. 2019; 25: 9446- 9457.

[25]

Zhang H , Nie X , Shi X , et al. Regulatory mechanisms of the wnt/beta-catenin pathway in diabetic cutaneous ulcers. Front Pharmacol. 2018, 9: 1114.

[26]

Cao Y , Xu L , Yang X , et al. The potential role of cycloastragenol in promoting diabetic wound repair in vitro. BioMed Res Int. 2019; 18: 7023950.

[27]

Chen PY , Qin L , Li G , et al. Endothelial TGF-beta signalling drives vascular inflammation and atherosclerosis. Nat Metab. 2019; 1 (9): 912- 926.

[28]

Sun Z , Liu C , Chen Q , et al. Effects of Xiangpi Shengji ointment on EMT in wound tissues of diabetic ulcer rats. Shaanxi J Tradit Chin Med. 2022; 43 (12): 1664- 1668.

[29]

Zhuo S , Qiao X , Chen J , et al. Mechanism of Fufang Yuyang powder on diabetic skin ulcers healing. Chin J Exp Tradit Med Formulae. 2015; 21 (04): 115- 119.

[30]

Zhang C , Chen L , Zhao W , et al. Danhuang powder promotes the wound healing of diabetic foot ulcer through transforming growth factor-β1/Smad3 signaling pathway in rats. Chin J Clin Pharmacol Therapeut. 2020; 36 (21): 3473- 3476.

[31]

Guo J , Hu Z , Yan F , et al. Angelica dahurica promoted angiogenesis and accelerated wound healing in db/db mice via the HIF-1α/PDGF-β signaling pathway. Free Radic Biol Med. 2020; 160: 447- 457.

[32]

Wang J , Wang L , Zhou H , et al. The isolation, structural features and biological activities of polysaccharide from Ligusticum chuanxiong: a review. Carbohydr Polym. 2022; 285: 118971.

[33]

Cao YJ , Pu ZJ , Tang YP , et al. Advances in bio-active constituents, pharmacology and clinical applications of rhubarb. Chin Med. 2017; 12 (1): 36.

[34]

Wang B , Zhang X , Zhao Y , et al. Observations on the effect of BaWeiGuWeiGao under the guidance of the four sides theory in the treatment of diabetic foot ulcer of damp-heat-toxic type. Shandong Med J. 2019; 59 (26): 68- 70.

[35]

Lou P . Clinical Efficacy of Ulcer Oil in Promoting the Healing of Diabetic Foot Ulcers. BUCM. 2023: 1- 9.

[36]

Lee JC , Kandula S , Sherber NS . Beyond wet-to-dry: a rational approach to treating chronic wounds. Eplasty. 2009; 9: e14.

[37]

Sim P , Strudwick XL , Song Y , Cowin AJ , Garg S . Influence of acidic pH on wound healing in vivo: a novel perspective for wound treatment. Int J Mol Sci. 2022; 23 (21). 13655.

[38]

Dilixiati K , Chen Z , Liu X . Clinical study of vacuum sealing drainage combined with autologous skin grafting under oxygen supply in the treatment of refractory diabetic foot ulcer. Chin J Inj Repair Wound Healing, Electron. 2022; 17 (01): 25- 31.

[39]

Wang Y , Xu X , Lu P . Clinical efficacy of licorice oil in treating wounds after diabetic foot skin grafting. Mod Chin Med. 2024; 26 (07): 1260- 1264.

[40]

Cardinal M , Eisenbud DE , Armstrong DG , et al. Serial surgical debridement: a retrospective study on clinical outcomes in chronic lower extremity wounds. Wound Repair Regen. 2009; 17 (3): 306- 311.

[41]

Barwick A , Tessier J , Mirow J , De Jonge XJ , Chuter V . Computed tomography derived bone density measurement in the diabetic foot. J Foot Ankle Res. 2017; 10 (1): 11.

[42]

Yang L , Rong GC , Wu QN . Diabetic foot ulcer: challenges and future. World J Diabetes. 2022; 13 (12): 1014- 1034.

[43]

Ji S , Liu X , Huang J , et al. Consensus on the application of negative pressure wound therapy of diabetic foot wounds. Burns Trauma. 2021; 9: tkab018.

[44]

Li J , Wang HY , Yang YF , Wang A , Shi Y , Cui T . Efficacy of the combination of Chinese herbal medicine and negative pressure wound therapy in the treatment of patients with diabetic foot ulcer: a meta-analysis. Int Wound J. 2024; 21 (4): e14536.

[45]

Marti-Carvajal AJ , Gluud C , Nicola S , et al. Growth factors for treating diabetic foot ulcers. Cochrane Database Syst Rev. 2015; 2015 (10): D8548.

[46]

Liu Y , Liu Y , Deng J , Li W , Nie X . Fibroblast growth factor in diabetic foot ulcer: progress and therapeutic prospects. Front Endocrinol. 2021; 12: 744868.

[47]

Li P , Chen S , Gao X , et al. Application of hospital-community-family care model in patients with diabetic foot who underwent transverse tibial osteotomy. J. Mod. Med. Health. 2024; 40 (09): 1584- 1588.

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