Bayesian Inference via GeTex-OTS Based Stochastic Synapse for Uncertainty-Aware Medical Diagnostics

Xinyu Wen , Lun Wang , Kuan Wang , Vivian Zhao , Zixuan Liu , Kexun He , Jianguo Yang , Hao Tong , Xiangshui Miao , Yuhui He

SmartMat ›› 2026, Vol. 7 ›› Issue (1) : e70062

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SmartMat ›› 2026, Vol. 7 ›› Issue (1) :e70062 DOI: 10.1002/smm2.70062
RESEARCH ARTICLE
Bayesian Inference via GeTex-OTS Based Stochastic Synapse for Uncertainty-Aware Medical Diagnostics
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Abstract

Neuromorphic architectures leveraging stochastic device physics present a transformative approach for implementing probabilistic computing paradigms capable of intrinsic uncertainty quantification. In this work, we present a germanium-telluride-based ovonic threshold switch (GeTex-OTS) exhibiting inherent stochastic dynamics, integrated into a compact 1-selector-1-transistor-1-resistor (1S1T1R) synaptic unit. The OTS devices are demonstrated within an 8K-array, confirming the future scalability for neuromorphic systems. Experimental validation on the GeTex devices shows stable Gaussian-distributed threshold voltage fluctuations (σ = 100 mV), enabling precise control of synaptic activation probability through input pulse modulation. Utilizing this intrinsic stochasticity, we implement mini hardware realization of a Monte Carlo Dropconnect (MC-Dropconnect) neural network, directly demonstrating the feasibility of the system. Applied to COVID-19 diagnosis using chest X-ray images, our system achieves robust uncertainty quantification through predictive entropy, improving classification accuracy to 98.1%, compared to 96.0% with a deterministic baseline. This uncertainty-aware hardware design strategy provides a scalable pathway for implementing energy-efficient neuromorphic systems with native uncertainty estimation capabilities.

Keywords

Monte Carlo dropconnect / ovonic threshold switch / probabilistic computing / stochastic synapse / uncertainty-aware

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Xinyu Wen, Lun Wang, Kuan Wang, Vivian Zhao, Zixuan Liu, Kexun He, Jianguo Yang, Hao Tong, Xiangshui Miao, Yuhui He. Bayesian Inference via GeTex-OTS Based Stochastic Synapse for Uncertainty-Aware Medical Diagnostics. SmartMat, 2026, 7(1): e70062 DOI:10.1002/smm2.70062

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