Objective: To investigate the impact of donepezil on emotional responses, cognitive function, and inflammatory factors in patients with Hashimoto's thyroiditis (HT).
Methods: A total of 109 patients with Hashimoto's thyroiditis treated in the Department of Endocrinology at Huangshan Shoukang Hospital between February 2021 and May 2024 were selected for this study. The patients were randomly divided into a treatment group (n = 54) and a control group (n = 55) using a random number table. The treatment group was administered donepezil hydrochloride tablets and vitamin C tablets orally in the morning on an empty stomach, while the control group received only vitamin C tablets under the same conditions. Both groups followed this regimen for three months. Outcomes were assessed using the Mini-Mental State Examination (MMSE), Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), thyroid hormone levels, and inflammatory markers.
Results: There were no statistically significant differences in thyroid hormone levels (T3, T4, TSH) or thyroid antibodies (TGAb, TPOAb) between the two groups before or after treatment (P > 0.05). Prior to treatment, MMSE, SAS, and SDS scores were comparable between the groups (P > 0.05). After treatment, MMSE scores in the treatment group were significantly higher, while SAS and SDS scores were significantly lower compared to the control group (P < 0.05). Additionally, no baseline differences in inflammatory factors were observed (P > 0.05), but after treatment, serum levels of IL-6, IL-4, IL-1β, and TNF-α were significantly lower in the treatment group compared to the control group (P < 0.05).
Conclusion: Donepezil can improve cognitive function and emotional responses in patients with Hashimoto's thyroiditis, which may be related to the downregulation of key inflammatory factors.
Declarations
Not applicable.
Authors' contributions
Chengwu Wang: Conceptualization, Methodology, Software. Xuelian Jiang: Data curation, Writing- Original draft preparation. Xiumei Sun: Visualization, Investigation. Defa Zhu: Supervision. Wenlu Guo: Software, Validation. Fen Wang: Writing- Reviewing and Editing.
Ethics approval and consent to participate
The study received approval from the medical ethics committee of Huangshan Shoukang Hospital (2023-LC-14).
Consent for publication
Not applicable.
Availability of data and materials
Not applicable.
Funding
This study was supported by the Program of National Natural Science Foundation of China (82300876).
Declarations of Competing interests
The authors declare that they have no competing interests.
Acknowledgements
Not applicable.
Authors' other information
Not applicable.
| [1] |
Xu SJ, Qi S, Shang JW, et al. Distribution of clinical symptoms and syndrome in enthyroid Hashimoto thyroiditis patients (Chinese). China Med Herald. 2022; 19(29):134-138. https://doi.org/10.20047/j.issn1673-7210.2022.29.31
|
| [2] |
Zhang X, Lian S, Zhang Y, et al. Efficacy and safety of donepezil for mild cognitive impairment: a systematic review and meta-analysis(Chinese). Clin Neurol Neurosurg. 2022; 213(42):107134.
|
| [3] |
Chen Y, Li SS, Wang WY, et al. A randomized controlled study:qingying powder in improving depression,anxiety and antibody disorder in patients with hashimoto thyroiditis complicated with subclinical hypothyroidism (Chinese). Tianjin J Tradit Chinese Med. 2024; 41(1):24-28. https://doi.org/10.11656/j.issn.1672-1519.2024.01.06
|
| [4] |
Berthier ML, Edelkraut L, López-González FJ, et al. Donepezil alone and combined with intensive language-action therapy on depression and apathy in chronic post-stroke aphasia: a feasibility study. Brain Lang. 2023; 236:105205. https://doi.org/10.1016/j.bandl.2022.105205
|
| [5] |
Huang MC, Weng ZC, Lin CY. Efficacy of different doses donepezil combined with memantine in the treatment of Alzheimer's disease:a comparative study (Chinese). Guangxi Med J. 2023; 45(3):257-261. https://doi.org/10.11675/j.issn.0253-4304.2023.03.01
|
| [6] |
Wang P, Jin Y, Mei R, et al. Effect of Shenghui Yizhi decoction combined with donepezil hydrochloride on behavioral and psychological symptoms of patients with mild to moderate Alzheimer's disease (Chinese). Chinese J Basic Med Tradit Chinese Med. 2024; 30(3):495-499.
|
| [7] |
Ge JB, Xu YJ, Wang C. Internal Medicine. Ninth Edition Beijing: People's Medical Publishing House; 2018:692-694.
|
| [8] |
Liu XY, Peng J, Xia ZY. Eight methods of Fuzheng Xiaoying for treating Hashimoto's thyroiditis (Chinese). Chinese J Clin Healthcare. 2020; 23(5):717-720. https://doi.org/10.3969/J.issn.1672-6790.2019.05.035
|
| [9] |
Tao YT, Wu JM. Effects of Donepezil hydrochloride regulating lncRNA GAS 5 on cognitive dysfunction and inflammatory response in vascular dementia mice (Chinese). Chinese J Integr Med Cardio/Cerebrovasc Dis. 2024; 22(7):1247-1251. https://doi.org/10.12102/j.issn.1672-1349.2024.07.014
|
| [10] |
Byers AL, Yaffe K. Depression and risk of developing dementia(Chinese). Nat Rev Neurol. 2021; 7(6):323-331.
|
| [11] |
Wang Y, Sun J, He MM, et al. Analysis of the relationship between serum ENO1Ab level and mild cognitive impairment in Hashimoto's thy-roiditis patients with normal thyroid function (Chinese). Chinese J N Clin Med. 2023; 16(9):946-950. https://doi.org/10.3969/j.issn.1674-3806.2023.09.14
|
| [12] |
Chen DY, Liao HJ, Yan HR, et al. Study on the effect of Yi'naokang capsules combined with donepezil hydrochloride tablets on patients with post-stroke cognitive impairment (Chinese). Tradit Chinese Drug Res Clin Pharmacol. 2023; 34(12):1793-1798. https://doi.org/10.19378/j.issn.1003-9783.2023.12.017
|
| [13] |
Wang AA, Li WJ, Huang WQ, et al. Clinical research of qingling granule combined with donepezil hydrochloride in the treatment of cognitive dysfunction after stroke (Chinese). Anhui Med Pharma J. 2022; 26(12):2524-2528. https://doi.org/10.3969/j.issn.1009-6469.2022.12.042
|
| [14] |
Nagahara AH, Tuszynski MH. Potential therapeutic uses of BDNF in neurological and psychiatric disorders. Nat Rev Drug Discov. 2011; 10(3):209-219. https://doi.org/10.1038/nrd3366
|
| [15] |
Bai FF, Li T, Li XZ, et al. Efficacy and safety of Donepezil hydrochloride in the treatment of refractory senile depressive disorder (Chinese). Pract Geriatr. 2020; 34(12):1292-1294. https://doi.org/10.3969/j.issn.1003-9198.2020.12.021
|
| [16] |
Wang N, Sun Y, Yang H, et al. Hashimoto's thyroiditis induces hippocampus-dependent cognitive alterations by impairing astrocytes in euthyroid mice. Thyroid. 2021; 31(3):482-493. https://doi.org/10.1089/thy.2020.0139
|
| [17] |
Cai YJ, Wang F, Chen ZX, et al. Hashimoto's thyroiditis induces neuroinflammation and emotional alterations in euthyroid mice. J Neuroinflammation. 2018; 15(1):299. https://doi.org/10.1186/s12974-018-1341-z
|
| [18] |
Hu XJ, Zhang AG, Zhang L, et al. Difference and correlation analysis of serum inflammatory factors in patients with and without psychotic symptoms with major depressive episode (Chinese). Anhui Med J. 2021; 42(12):1381-1383. https://doi.org/10.3969/j.issn.1000-0399.2021.12.011
|
| [19] |
Wang ZG, Yang F, Wang XB, et al. Study on curative effect and mechanism of using donepezil assisted with Bushen Tianjing Yisui decoction in the treatment of Alzheimer's disease (Chinese). J Sichuan Tradit Chinese Med. 2022; 40(5):172-175.
|
| [20] |
Wang ZG, Chen YX, Yin CP, et al. Research progress on the effect of inflammation on perioperative neurocognitive disorders (Chinese). J of Clin Anesthesiol. 2023; 39(2):189-192. https://doi.org/10.12089/jca.2023.02.016
|
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