Life Metabolism >

2023 , Vol. 2 >Issue 1: 3 - 5

DOI: https://doi.org/10.1093/lifemeta/loac016

Adipose triglyceride lipase: the first transacylase for FAHFAs

  • Juan Wang 1 ,
  • Guosheng Liang , 2 ,
  • Tong-Jin Zhao , 1
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  • 1. State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Zhongshan Hospital, Fudan University, Shanghai 200438, China
  • 2. Department of Molecular Genetics and Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States
guosheng.liang@utsouthwestern.edu
zhaotj@fudan.edu.cn

Received date: 28 Jul 2022

Accepted date: 08 Aug 2022

Published date: 14 Sep 2023

Copyright

2023 The Author(s) 2023. Published by Oxford University Press on behalf of Higher Education Press.
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Cite this article

Juan Wang , Guosheng Liang , Tong-Jin Zhao . Adipose triglyceride lipase: the first transacylase for FAHFAs[J]. Life Metabolism, 2023 , 2(1) : 3 -5 . DOI: 10.1093/lifemeta/loac016

References

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Tan D, Ertunc ME, Konduri Set al. Discovery of FAHFA-containing triacylglycerols and their metabolic regulation. J Am Chem Soc 2019; 141: 8798- 806.

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Nelson A, Chow LS, Hughey CCet al. Artifactual FA dimers mimic FAHFA signals in untargeted metabolomics pipelines. J Lipid Res 2022; 63: 100201.

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Patel R, SantoroA , Hofer Pet al. ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids. Nature 2022; 606: 968- 75.

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Jenkins CM, Mancuso DJ, Yan Wet al. Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J Biol Chem 2004; 279: 48968- 75.

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Brejchova K, Radner FPW, Balas Let al. Distinct roles of adipose triglyceride lipase and hormone-sensitive lipase in the catabolism of triacylglycerol estolides. Proc Natl Acad Sci USA 2021; 118: e2020999118.

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Zechner R, Kienesberger PC, Haemmerle Get al. Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores. J Lipid Res 2009; 50: 3- 21.

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