Adipose triglyceride lipase: the first transacylase for FAHFAs

References

[1] Brejchova K, Balas L, Paluchova Vet al. Understanding FAHFAs: From structure to metabolic regulation. Prog Lipid Res. 2020; 79: 101053.

[2] Yore MM, Syed I, Moraes-Vieira PMet al. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell 2014; 159: 318- 32.

[3] Tan D, Ertunc ME, Konduri Set al. Discovery of FAHFA-containing triacylglycerols and their metabolic regulation. J Am Chem Soc 2019; 141: 8798- 806.

[4] Nelson A, Chow LS, Hughey CCet al. Artifactual FA dimers mimic FAHFA signals in untargeted metabolomics pipelines. J Lipid Res 2022; 63: 100201.

[5] Patel R, SantoroA , Hofer Pet al. ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids. Nature 2022; 606: 968- 75.

[6] Jenkins CM, Mancuso DJ, Yan Wet al. Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J Biol Chem 2004; 279: 48968- 75.

[7] Zhang X, Zhang CC, Yang Het al. An epistatic interaction between Pnpla2 and lipe reveals new pathways of adipose tissue lipolysis. Cells 2019; 8: 395.

[8] Brejchova K, Radner FPW, Balas Let al. Distinct roles of adipose triglyceride lipase and hormone-sensitive lipase in the catabolism of triacylglycerol estolides. Proc Natl Acad Sci USA 2021; 118: e2020999118.

[9] Zechner R, Kienesberger PC, Haemmerle Get al. Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores. J Lipid Res 2009; 50: 3- 21.

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