2025-12-15 , Volume 4 Issue 6

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• Targeting complex IV to alter the tumor microenvironment and boost macrophage antitumor immunity

  Thomas Pfefer , Luke A. J. O'Neill

  2025, 4(6): loaf032-. https://doi.org/10.1093/lifemeta/loaf032

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• The pathogenic theory of homeostasis threshold deviation (HTD) in wide-range oscillatory physiological parameters: novel perspectives for hypertension and metabolic disease treatment

  Wei Sun , Jin-Yu Sun , Xiangqing Kong

  2025, 4(6): loaf029-. https://doi.org/10.1093/lifemeta/loaf029

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• RME-1-associated recycling endosomes participate in vitellogenin secretion in Caenorhabditis elegans

  Chao Zhai , Meng-Qiu Dong

  2025, 4(6): loaf026-. https://doi.org/10.1093/lifemeta/loaf026

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• Well Met: RIPK1 senses S-adenosyl methionine to ensure cell survival

  Piyush Sharma , Douglas R. Green

  2025, 4(6): loaf033-. https://doi.org/10.1093/lifemeta/loaf033

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• A reductive uric acid degradation pathway in anaerobic bacteria

  Zhi Li , Wei Meng , Zihan Gao , Wanli Peng , Zhandong Hu , Jianhao Zhang , Yining Wang , Xiaoxia Wu , Zipeng Zhao , Chuyuan Zhang , Zhuohao Tang , Zhujun Nie , Shaohua Wu , Benjuan Wu , Hui Zheng , Duqiang Luo , Yang Tong , Yiling Hu , Zehan Hu , Yifeng Wei , Yan Zhang

  2025, 4(6): loaf031-. https://doi.org/10.1093/lifemeta/loaf031

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• The brown fat-enriched exosomal miR-206-3p attenuates hepatic lipogenesis by decreasing pentose phosphate pathway

  Li-Jie Yang , Qiu-kai Tang , Lei Wang , Yan-Jue Song , Zhen-Yu Xu , Xi-Ni Ma , Yang Liu , Shu-Wen Qian , Qi-Qun Tang , Yan Tang

  2025, 4(6): loaf028-. https://doi.org/10.1093/lifemeta/loaf028

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• Energy stress-induced PKCζ S-glutathionylation is essential for LKB1 cytoplasmic translocation and AMPK activation

  Junjie Fei , Shuhan Yu , Mingzhe Xu , Yang Liu , Guoqiang Wang , Xueqing Li , Xinyue Yu , Yifan Zhang , Wenhua Zhang , Yang Wang , Mengmeng Niu , Yujun Zhang , Yang Cao , Zhi-Xiong Jim Xiao , Yong Yi

  2025, 4(6): loaf027-. https://doi.org/10.1093/lifemeta/loaf027

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