2025-10-15 , Volume 4 Issue 5

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• Cryo-EM structure of the human MON1A-CCZ1-RAB7A complex provides insights into nucleotide exchange mechanism

  Xinna Li , Dan Li , Dan Tang , Xiaofang Huang , Hui Bao , Jiawei Wang , Shiqian Qi

  2025, 4(5): loaf017-. https://doi.org/10.1093/lifemeta/loaf017

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• Hyaluronidase-1 mediates postprandial suppression of hepatic gluconeogenesis

  Xi Chen , Sophie Dogné , Yanru Deng , Huiqiao Li , Jieyi Meng , Charlise Giang , Jan-Bernd Funcke , Leon G. Straub , Michelle Dias , Sundararajah Thevananther , Qiang Tong , Abu Hena Mostafa Kamal , Chandra Shekar R. Ambati , Yu'e Liu , Nagireddy Putluri , Xia Gao , Miao-Hsueh Chen , Dongyin Guan , Hari Krishna Yalamanchili , Shangang Zhao , Nathalie Caron , Yi Zhu

  2025, 4(5): loaf016-. https://doi.org/10.1093/lifemeta/loaf016

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• Mom sweet, baby sad

  Dongliang Lu , Xun Huang

  2025, 4(5): loaf030-. https://doi.org/10.1093/lifemeta/loaf030

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• MDVs bridge metabolite signals to mitochondrial fitness

  Guang Lu , Han-Ming Shen

  2025, 4(5): loaf022-. https://doi.org/10.1093/lifemeta/loaf022

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• Spatially segregated multiomics decodes metformin-mediated function-specific metabolic characteristics in diabetic kidney disease

  Shi Qiu , Dandan Xie , Sifan Guo , Zhibo Wang , Xian Wang , Ying Cai , Chunsheng Lin , Hong Yao , Yu Guan , Qiqi Zhao , Qiang Yang , Yiqiang Xie , Songqi Tang , Aihua Zhang

  2025, 4(5): loaf019-. https://doi.org/10.1093/lifemeta/loaf019

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• Structural insights into RAB7A activation: a mammalian perspective on the MON1A-CCZ1 GEF complex

  Life Metabolism Editorial Team

  2025, 4(5): loaf021-. https://doi.org/10.1093/lifemeta/loaf021

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• Weight loss maintenance after tirzepatide cessation in people with overweight/obesity: a real-world follow-up of the phase 3 SURMOUNT-CN trial

  Congling Chen , Zhen Ying , Qi Tang , Lin Zhao , Yibing Lu , Xiaofang Fan , Lan Xu , Si Si , Yuanyuan Li , Jiawei Xu , Yihua Wang , Yu Dong , Xiaoying Li , Ying Chen

  2025, 4(5): loaf024-. https://doi.org/10.1093/lifemeta/loaf024

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