Cognitive control of metabolism: How cold memories drive whole-body thermoregulation

Jan Mohammad Omar , Yihui Liu

Frigid Zone Medicine ›› 2025, Vol. 5 ›› Issue (2) : 124 -125.

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Frigid Zone Medicine ›› 2025, Vol. 5 ›› Issue (2) :124 -125. DOI: 10.1515/fzm-2025-0014
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Cognitive control of metabolism: How cold memories drive whole-body thermoregulation

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Jan Mohammad Omar, Yihui Liu. Cognitive control of metabolism: How cold memories drive whole-body thermoregulation. Frigid Zone Medicine, 2025, 5(2): 124-125 DOI:10.1515/fzm-2025-0014

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Acknowledgements

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Author contributions

Omar J M drafted the manuscript. Liu Y H edited and reviewed the manuscript.

Use of large language models, AI and machine learning tools

No Generative Al was used in the preparation of this manuscript.

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The authors declare no competing financial interest.

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References

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Muñoz Zamora A, Douglas A, Conway P B, et al. Cold memories control whole-body thermoregulatory responses. Nature, 2025; 641(8064): 942-951.

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Josselyn S A, Tonegawa S. Memory engrams: recalling the past and imagining the future. Science, 2020; 367(6473): 4325.

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Cypess A M, Weiner LS, Roberts-Toler C, et al. Activation of human brown adipose tissue by a β3-adrenergic receptor agonist. Cell Metab, 2015; 21(1): 33-38.

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Morrison S F, Nakamura K. Central neural pathways for thermoregulation. Front Biosci (Landmark Ed), 2011; 16(1): 74-104.

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Grillon C, Baas J M, Cornwell B, et al. Context conditioning and behavioral avoidance in a virtual reality environment: effect of predictability. Biol Psychiatry, 2006; 60(7): 752-759.

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Chevalier C, Stojanović O, Colin D J, et al. Gut microbiota orchestrates energy homeostasis during cold. Cell, 2015; 163(6): 1360-1374.

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Halder R, Hennion M, Vidal R O, et al. DNA methylation changes in plasticity genes accompany the formation and maintenance of memory. Nat Neurosci, 2016; 19(1): 102-110.

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