Multifunctional modification of Fe₃O₄ nanoparticles for diagnosis and treatment of diseases: A review

Abstract

With the rapid improvements in nanomaterials and imaging technology, great progresses have been made in diagnosis and treatment of diseases during the past decades. Fe₃O₄ magnetic nanoparticles (MNPs) with good biocompatibility and superparamagnetic property are usually used as contrast agent for diagnosis of diseases in magnetic resonance imaging (MRI). Currently, the combination of multiple imaging technologies has been considered as new tendency in diagnosis and treatment of diseases, which could enhance the accuracy and reliability of disease diagnosis and provide new strategies for disease treatment. Therefore, novel contrast agents used for multifunctional imaging are urgently needed. Fe₃O₄ MNPs are believed to be a potential candidate for construction of multifunctional platform in diagnosis and treatment of diseases. In recent years, there are a plethora of studies concerning the construction of multifunctional platform presented based on Fe₃O₄ MNPs. In this review, we introduce fabrication methods and modification strategies of Fe₃O₄ MNPs, expecting great improvements for diagnosis and treatment of diseases in the future.

Key words： Fe₃O₄ MNPs; preparation methods; modification strategy; multifunctional platform

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Grant Nos. 11502158, 11632013 and 11802197). The support of the Shanxi Provincial Key Research and Development Project, China (Grant Nos. 201803D421060, 201903D421064 and 201803D421076), the Natural Science Foundation of Shanxi Province, China (201901D111078 and 201901D111077), and the Shanxi Scholarship Council of China (No. HGKY2019037) are also acknowledged with gratitude.

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