Heat preservation, antifouling, hemostatic and antibacterial aerogel wound dressings for emergency treatment

Abstract

Hemostatic dressings with multiple functions are superior to current hemostatic dressings for use in the complex situation of emergency accidents. In particular, the existing dressings lack consideration for the prevention of hypothermic shock after massive hemorrhage. In this study, gelatin (GN) and oxidized pectin (OP) were used for Schiff base cross-linking, and then polyvinyl alcohol (PVA) solution mixed with hemostatic caffeic acid (CA) was introduced to obtain aerogel substrate material (CB) after lyophilization. Polydimethylsiloxane (PDMS) and silver nanowires (Ag NWs) were used to construct a hydrophobic layer, an antibacterial layer and an infrared reflective layer on both sides of CB to prepare a multifunctional aerogel wound dressing with heat preservation, antifouling, hemostasis and antibacterial properties (PDMS-Ag NW-CB). The results showed that the infrared transmittance of PDMS-Ag NW-CB is almost 0, so that thermal energy loss from the body is minimized. The contact angles with water and blood are 129° and 120°, respectively, which have the effect of antifouling. This dressing can absorb blood quickly within 10 min, adhere to and gather platelets, and achieve hemostasis. It has good antibacterial and biocompatibility. Therefore, PDMS-Ag NW-CB has great potential in application to emergency treatment.

Graphical abstract

Keywords

heat preservation / hemostasis / antifouling / antibacterial / wound dressing

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Disclosure of potential conflicts of interest

The authors declare no competing financial interest.

Acknowledgements

This work was supported financially by funding from the National Natural Science Foundation of China (Grant Nos. 21866028, 21367022, 51662036, and 82060646), the Graduate Student Scientific Research Innovation Projects in Xinjiang Uygur Autonomous Region (XJGRI2017046), the Achievements Transformation and Technique Extension Projection in Shihezi University (CGZH201603), the Regional Innovation Guidance Program of Bingtuan (2021BB033), and the Open Foundation of Engineering Research Center of Materials-Oriented Chemical Engineering of Xinjiang Bingtuan (2016BTRC005).

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