Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma
Received date: 01 May 2015
Accepted date: 10 Dec 2015
Published date: 31 Mar 2016
Copyright
Hepatocellular carcinoma (HCC) is a lethal liver malignancy worldwide. In this study, we reported that protein phosphatase magnesium-dependent 1δ (PPM1D) was highly expressed in the majority of HCC cases (approximately 59%) and significantly associated with high serum α-fetoprotein (AFP) level (P= 0.044). Kaplan-Meier and Cox regression data indicated that PPM1D overexpression was an independent predictor of HCC-specific overall survival (HR, 2.799; 95% CI, 1.346–5.818, P = 0.006). Overexpressing PPM1D promoted cell viability and invasion, whereas RNA interference-mediated knockdown of PPM1D inhibited proliferation, invasion, and migration of cultured HCC cells. In addition, PPM1D suppression by small interfering RNA decreased the tumorigenicity of HCC cells in vivo. Overall, results suggest that PPM1D is a potential prognostic marker and therapeutic target for HCC.
Key words: PPM1D; hepatocellular carcinoma; prognosis; target therapy
Zhi Xu , Chunxiang Cao , Haiyan Xia , Shujing Shi , Lingzhi Hong , Xiaowei Wei , Dongying Gu , Jianmin Bian , Zijun Liu , Wenbin Huang , Yixin Zhang , Song He , Nikki Pui-Yue Lee , Jinfei Chen . Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma[J]. Frontiers of Medicine, 2016 , 10(1) : 52 -60 . DOI: 10.1007/s11684-016-0433-3
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