2025, Vol.19 No.5
RRS1 is expressed in TE, PE, and EPI of the human blastocyst and regulates the proliferation, migration, and invasion of HTR-8/SVneo human trophoblasts. RRS1 knockdown and RNA-seq revealed differentially expressed genes enriched in diseases related with placental development. Human chorionic villus samples exhibited significantly reduced RRS1 expression in spontaneous abortion cases. Our results highlight the functional importance of RRS1 in human trophoblasts and early pregnancy loss. (Courtesy of Drs. Jie Qiao, Liying Yan, and Peng Yuan. See pages 831−841 by Yixuan Wu et al. for more information.)
2025, Vol.19 No.4
Knockdown of DBNDD2, a molecule that is differentially expressed following peripheral or central axotomy and up-regulated in DRG neurons during development, promotes neurite growth and axonal regeneration. (Courtesy of Drs. Sheng Yi and Leilei Gong. See pages 636−652 by Lan Zhang et al. for more information.)
2025, Vol.19 No.3
The cytoplasmic-mitochondrial shuttling of lactic acid (left) and mitochondrial lactate oxidation complex (right). MCT1 is inserted into the mitochondrial inner membrane, strongly interacting with its chaperone protein CD147, and is also associated with COX IV and mitochondrial lactate dehydrogenase B (LDHB). TCA, tricarboxylic acid cycle. Illustration created with BioRender.com. (Courtesy of Dr. Bo Huang. See pages 456−473 by Jingwei Ma et al. for more information.)
2025, Vol.19 No.2
Research pathway of Qin-Zhu-Liang-Xue decoction improving atopic dermatitis through GRα upregulation. (Courtesy of Drs. Yimei Tan, Su Li, and Xin Ma. See pages 134-148 by Keke Huang et al. for more information.)
2025, Vol.19 No.1
Research pathway of Qin-Zhu-Liang-Xue decoction improving atopic dermatitis through GRα upregulation. (Courtesy of Drs. Yimei Tan, Su Li, and Xin Ma. See pages 134-148 by Keke Huang et al. for more information.)