China’s biosafety/biosecurity governance: evolution, challenges, and architecture design

Kaiyuan Min , Yi Zhang , Jiangfeng Liu , Juntao Yang , Feng Cao , Zongchao Peng , Depei Liu

Front. Med. ›› 2025, Vol. 19 ›› Issue (5) : 871 -878.

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Front. Med. ›› 2025, Vol. 19 ›› Issue (5) : 871 -878. DOI: 10.1007/s11684-025-1158-y
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China’s biosafety/biosecurity governance: evolution, challenges, and architecture design

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Kaiyuan Min, Yi Zhang, Jiangfeng Liu, Juntao Yang, Feng Cao, Zongchao Peng, Depei Liu. China’s biosafety/biosecurity governance: evolution, challenges, and architecture design. Front. Med., 2025, 19(5): 871-878 DOI:10.1007/s11684-025-1158-y

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References

[1]

World Health Organization. 21st century health challenges: can the essential public health functions make a difference? Geneva: World Health Organization, 2021

[2]

Zhang XX , Jin YZ , Lu YH , Huang LL , Wu CX , Lv S , Chen Z , Xiang H , Zhou XN . Infectious disease control: from health security strengthening to health systems improvement at global level. Glob Health Res Policy 2023; 8(1): 38

[3]

Nordmann BD . Issues in biosecurity and biosafety. Int J Antimicrob Agents 2010; 36(Suppl 1): S66–S69

[4]

World Health Organization. Laboratory biosafety manual. 4th ed. Geneva: World Health Organization, 2020

[5]

European Parliament and Council: Directive 2000/54/EC on the protection of workers from risks related to exposure to biological agents at work. Official Journal of the European Union 2000 (L 262): 21–45

[6]

European Parliament and Council: Directive 2009/41/EC on the contained use of genetically modified micro-organisms. Official Journal of the European Union 2009 (L 125): 75–97

[7]

Gillum DR , Moritz R , Koblentz GD . Establishing a national biosafety and biosecurity agency for the United States. Front Bioeng Biotechnol 2024; 12: 1474120

[8]

Maehira Y , Spencer RC . Harmonization of biosafety and biosecurity standards for high-containment facilities in low- and middle-income countries: an approach from the perspective of occupational safety and Health. Front Public Health 2019; 7: 249

[9]

Beeckman DSA , Rüdelsheim P . Biosafety and biosecurity in containment: a regulatory overview. Front Bioeng Biotechnol 2020; 8: 650

[10]

Greely HT . CRISPR’d babies: human germline genome editing in the ‘He Jiankui affair’. J Law Biosci 2019; 6(1): 111–183

[11]

Zeng X , Jiang H , Yang G , Ou Y , Lu S , Jiang J , Lei R , Su L . Regulation and management of the biosecurity for synthetic biology. Synth Syst Biotechnol 2022; 7(2): 784–790

[12]

Doudna JA . The promise and challenge of therapeutic genome editing. Nature 2020; 578(7794): 229–236

[13]

Sun T , Song J , Wang M , Zhao C , Zhang W . Challenges and recent progress in the governance of biosecurity risks in the era of synthetic biology. J Biosaf Biosecur 2022; 4(1): 59–67

[14]

Namdeo SK , Zhang JY . Rethinking science diplomacy and global biosecurity: challenges, emerging practices and the way forward. Int Aff 2024; 100(6): 2623–2635

[15]

Xue Y , Shang L . Towards better governance on biosafety and biosecurity: China’s advances and perspectives in medical biotechnology legislation. Front Bioeng Biotechnol 2022; 10: 939295

[16]

BiosecurityLaw of the People’s Republic of China. Available at the website of the National People’s Congress of the People’s Republic of China. 2020

[17]

Cao C . China’s evolving biosafety/biosecurity legislations. J Law Biosci 2021; 8(1): lsab020

[18]

Liang H , Xiang X , Ma H , Yuan Z . History of and suggestions for China’s biosafety legislation. J Biosaf Biosecur 2019; 1(2): 134–139

[19]

Wu G . Laboratory biosafety in China: past, present, and future. Biosaf Health 2019; 1(2): 56–58

[20]

SunJ. Genetically modified foods in China: regulation, deregulation, or governance? In: Liu K-C, Racherla US. Innovation, Economic Development, and Intellectual Property in India and China: Comparing Six Economic Sectors. Singapore: Springer Nature Singapore, 2019: 347–366

[21]

Daza-RíosCParra-ValenciaJA. Biosecurity adherence using cooperation mechanisms: leveraging system thinking for effective strategic organizational biosecurity decision making. In: Qudrat-ullah H. Managing Complex Tasks with Systems Thinking. Cham: Springer Nature Switzerland, 2023: 305–322

[22]

Zhan Q , Liu D . A key player in biomedical sciences and clinical service in China, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC). J Mol Med (Berl) 2007; 85(8): 845–850

[23]

AboutCAAS. 2025. Available at the website of Chinese Academy of Agricultural Sciences

[24]

Wang L , Ren X , Cowling BJ , Zeng L , Geng M , Wu P , Li Z , Yu H , Gao G . Systematic review: national notifiable infectious disease surveillance system in China. Online J Public Health Inform 2019; 11(1): e414

[25]

BiologicalWeapons Convention National Implementation Measures Database. 2025. Available at the website of United Nations Institute For Disarmament Research

[26]

LiuA. Biosafety regulation in China: progress and challenges. In: Antonelli G, Qin T, Ferroni MV, Erwin A. Biodiversity Laws, Policies and Science in Europe, the United States and China. Cham: Springer Nature Switzerland, 2024: 253–268

[27]

Wang L , Wang Z , Ma Q , Fang G , Yang J . The development and reform of public health in China from 1949 to 2019. Global Health 2019; 15(1): 45

[28]

Yip W , Fu H , Chen AT , Zhai T , Jian W , Xu R , Pan J , Hu M , Zhou Z , Chen Q , Mao W , Sun Q , Chen W . 10 years of health-care reform in China: progress and gaps in Universal Health Coverage. Lancet 2019; 394(10204): 1192–1204

[29]

Tao W , Zeng Z , Dang H , Li P , Chuong L , Yue D , Wen J , Zhao R , Li W , Kominski G . Towards universal health coverage: achievements and challenges of 10 years of healthcare reform in China. BMJ Glob Health 2020; 5(3): e002087

[30]

Zhiming Y . Current status and future challenges of high-level biosafety laboratories in China. J Biosaf Biosecur 2019; 1(2): 123–127

[31]

Gupta A , Falkner R . The influence of the cartagena protocol on biosafety: comparing Mexico, China and South Africa. Glob Environ Polit 2006; 6(4): 23–55

[32]

Liu P , Guo Y , Qian X , Tang S , Li Z , Chen L . China’s distinctive engagement in global health. Lancet 2014; 384(9945): 793–804

[33]

Goldizen FC . From SARS to avian influenza: the role of international factors in China’s approach to infectious disease control. Ann Glob Health 2016; 82(1): 180–188

[34]

Song L , Joly Y . After He Jianku: China’s biotechnology regulation reforms. Med Law Int 2021; 21(2): 174–192

[35]

Bouey J . Strengthening China’s public health response system: from SARS to COVID-19. Am J Public Health 2020; 110(7): 939–940

[36]

Sachs JD , Karim SSA , Aknin L , Allen J , Brosbøl K , Colombo F , Barron GC , Espinosa MF , Gaspar V , Gaviria A , Haines A , Hotez PJ , Koundouri P , Bascuñán FL , Lee JK , Pate MA , Ramos G , Reddy KS , Serageldin I , Thwaites J , Vike-Freiberga V , Wang C , Were MK , Xue L , Bahadur C , Bottazzi ME , Bullen C , Laryea-Adjei G , Ben Amor Y , Karadag O , Lafortune G , Torres E , Barredo L , Bartels JGE , Joshi N , Hellard M , Huynh UK , Khandelwal S , Lazarus JV , Michie S . The Lancet Commission on lessons for the future from the COVID-19 pandemic. Lancet 2022; 400(10359): 1224–1280

[37]

ChenY. Fully implementing the overall national security outlook. 2024. Available at the website of Qiushi Online (in Chinese)

[38]

Huigang L , Cui H , Xiaoli Z , Zhiming Y . Significance of and outlook for the Biosecurity Law of the People’s Republic of China. J Biosaf Biosecur 2021; 3(1): 46–50

[39]

Decisionof the Standing Committee of the National People’s Congress on Amending the Agricultural Technology Promotion Law of the People’s Republic of ChinatheLaw on the Protection of Minors of the People’s Republic of ChinatheBiosecurity Law of the People’s Republic of China. 2024. Available at the website of the State Council of the People’s Republic of China

[40]

Zhang X , Zhao C , Shao MW , Chen YL , Liu P , Chen GQ . The roadmap of bioeconomy in China. Eng Biol 2022; 6(4): 71–81

[41]

FightingCOVID-19: China in Action. 2020. Available at the website of China SCIO

[42]

Zhang X , Wang C , Wang W , Zhang H . Inter-organizational collaboration after institutional reform in China: a perspective based on the revision of the emergency plan. Int J Disaster Risk Reduct 2023; 98: 104084

[43]

Scott I , Gong T . Coordinating government silos: challenges and opportunities. Glob Public Policy Gov 2021; 1(1): 20–38

[44]

Perkins D , Danskin K , Rowe AE , Livinski AA . The culture of biosafety, biosecurity, and responsible conduct in the life sciences: a comprehensive literature review. Appl Biosaf 2019; 24(1): 34–45

[45]

Diao Q , Long Y , Yang F , Nong C , Tang H , Zhou X , Zhu G , Ding Q . Biosafety management based upon risk assessment and monitoring: perspectives from a clinical laboratory, China. Risk Manag Healthc Policy 2024; 17: 2291–2303

[46]

Beam AL , Kohane IS . Big data and machine learning in health care. JAMA 2018; 319(13): 1317–1318

[47]

Nyangon J . Climate-proofing critical energy infrastructure: smart grids, artificial intelligence, and machine learning for power system resilience against extreme weather events. J Infrastruct Syst 2024; 30(1): 03124001

[48]

Ravì D , Wong C , Deligianni F , Berthelot M , Andreu-Perez J , Lo B , Yang GZ . Deep learning for health informatics. IEEE J Biomed Health Inform 2017; 21(1): 4–21

[49]

Burris S , Wagenaar AC , Swanson J , Ibrahim JK , Wood J , Mello MM . Making the case for laws that improve health: a framework for public health law research. Milbank Q 2010; 88(2): 169–210

[50]

Petkovic J , Magwood O , Lytvyn L , Khabsa J , Concannon TW , Welch V , Todhunter-Brown A , Palm ME , Akl EA , Mbuagbaw L , Arayssi T , Avey MT , Marusic A , Morley R , Saginur M , Slingers N , Texeira L , Ben Brahem A , Bhaumik S , Bou Akl I , Crowe S , Dormer L , Ekanem C , Lang E , Kianzad B , Kuchenmüller T , Moja L , Pottie K , Schünemann H , Tugwell P . Key issues for stakeholder engagement in the development of health and healthcare guidelines. Res Involv Engagem 2023; 9(1): 27

[51]

Mousmouti M . Making legislative effectiveness an operational concept: unfolding the effectiveness test as a conceptual tool for lawmaking. Eur J Risk Regul 2018; 9(3): 445–464

[52]

WorldHealth Organization. Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19). Geneva: World Health Organization, 2020

[53]

Zinsstag J , Kaiser-Grolimund A , Heitz-Tokpa K , Sreedharan R , Lubroth J , Caya F , Stone M , Brown H , Bonfoh B , Dobell E , Morgan D , Homaira N , Kock R , Hattendorf J , Crump L , Mauti S , del Rio Vilas V , Saikat S , Zumla A , Heymann D , Dar O , de la Rocque S . Advancing One human-animal-environment Health for global health security: what does the evidence say. Lancet 2023; 401(10376): 591–604

[54]

Valente TW . Network interventions. Science 2012; 337(6090): 49–53

[55]

Kickbusch I . BRICS’ contributions to the global health agenda. Bull World Health Organ 2014; 92(6): 463–464

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