
Long-acting lenacapavir is a breakthrough for preventing HIV infection, but HIV vaccine research must continue
Caijun Sun, Linghua Li, Pingchao Li, Weiping Cai, Xiaoping Tang, Yiming Shao, Ling Chen
Front. Med. ››
Long-acting lenacapavir is a breakthrough for preventing HIV infection, but HIV vaccine research must continue
[1] |
UNAIDS
|
[2] |
Sun C , Zuo T , Wen Z . First clinical study of germline-targeting strategy: one step closer to a successful bnAb-based HIV vaccine. Innovation (Camb) 2023; 4(1): 100374
CrossRef
Google scholar
|
[3] |
Segal-Maurer S , DeJesus E , Stellbrink HJ , Castagna A , Richmond GJ , Sinclair GI , Siripassorn K , Ruane PJ , Berhe M , Wang H , Margot NA , Dvory-Sobol H , Hyland RH , Brainard DM , Rhee MS , Baeten JM , Molina JM; CAPELLA Study Investigators . Capsid inhibition with lenacapavir in multidrug-resistant HIV-1 infection. N Engl J Med 2022; 386(19): 1793–1803
CrossRef
Google scholar
|
[4] |
Rai MA , Blazkova J , Kardava L , Justement JS , Shi V , Manning MR , Shahid A , Dong W , Kennedy BD , Sewack AB , Higgins J , Buckner CM , Gittens K , West RE 3rd , Devanathan AS , Mangusan R , Lurain K , Ramaswami R , Yarchoan R , Sneller MC , Pau AK , Brumme ZL , Moir S , Chun TW . Sustained virologic suppression of multidrug-resistant HIV in an individual treated with anti-CD4 domain 1 antibody and lenacapavir. Nat Med 2025; 31(2): 427–432
CrossRef
Google scholar
|
[5] |
Grant RM , Lama JR , Anderson PL , McMahan V , Liu AY , Vargas L , Goicochea P , Casapía M , Guanira-Carranza JV , Ramirez-Cardich ME , Montoya-Herrera O , Fernández T , Veloso VG , Buchbinder SP , Chariyalertsak S , Schechter M , Bekker LG , Mayer KH , Kallás EG , Amico KR , Mulligan K , Bushman LR , Hance RJ , Ganoza C , Defechereux P , Postle B , Wang F , McConnell JJ , Zheng JH , Lee J , Rooney JF , Jaffe HS , Martinez AI , Burns DN , Glidden DV; iPrEx Study Team . Pre-exposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med 2010; 363(27): 2587–2599
CrossRef
Google scholar
|
[6] |
Wen Z , Shi M , Sun C . Treatment as the best prevention: twice-yearly lenacapavir, a game changer in ending the AIDS epidemic. Viruses 2024; 16(9): 1368
CrossRef
Google scholar
|
[7] |
Landovitz RJ , Donnell D , Clement ME , Hanscom B , Cottle L , Coelho L , Cabello R , Chariyalertsak S , Dunne EF , Frank I , Gallardo-Cartagena JA , Gaur AH , Gonzales P , Tran HV , Hinojosa JC , Kallas EG , Kelley CF , Losso MH , Madruga JV , Middelkoop K , Phanuphak N , Santos B , Sued O , Valencia Huamaní J , Overton ET , Swaminathan S , Del Rio C , Gulick RM , Richardson P , Sullivan P , Piwowar-Manning E , Marzinke M , Hendrix C , Li M , Wang Z , Marrazzo J , Daar E , Asmelash A , Brown TT , Anderson P , Eshleman SH , Bryan M , Blanchette C , Lucas J , Psaros C , Safren S , Sugarman J , Scott H , Eron JJ , Fields SD , Sista ND , Gomez-Feliciano K , Jennings A , Kofron RM , Holtz TH , Shin K , Rooney JF , Smith KY , Spreen W , Margolis D , Rinehart A , Adeyeye A , Cohen MS , McCauley M , Grinsztejn B; HPTN 083 Study Team . Cabotegravir for HIV prevention in cisgender men and transgender women. N Engl J Med 2021; 385(7): 595–608
CrossRef
Google scholar
|
[8] |
Bekker LG , Das M , Abdool Karim Q , Ahmed K , Batting J , Brumskine W , Gill K , Harkoo I , Jaggernath M , Kigozi G , Kiwanuka N , Kotze P , Lebina L , Louw CE , Malahleha M , Manentsa M , Mansoor LE , Moodley D , Naicker V , Naidoo L , Naidoo M , Nair G , Ndlovu N , Palanee-Phillips T , Panchia R , Pillay S , Potloane D , Selepe P , Singh N , Singh Y , Spooner E , Ward AM , Zwane Z , Ebrahimi R , Zhao Y , Kintu A , Deaton C , Carter CC , Baeten JM , Matovu Kiweewa F; PURPOSE 1 Study Team . Twice-yearly lenacapavir or daily F/TAF for HIV prevention in cisgender women. N Engl J Med 2024; 391(13): 1179–1192
CrossRef
Google scholar
|
[9] |
KelleyCFAcevedo-QuiñonesMAgwuALAvihingsanonABensonPBlumenthalJBrinsonCBritesCCahnPCantosVDClarkJClementMCreticosCCrofootGDiazRSDoblecki-LewisSGallardo-CartagenaJAGaurAGrinsztejnBHasslerSHinojosaJCHodgeTKaplanRLacerdaMLaMarcaALossoMHValdezMadruga JMayerKHMillsAMounzerKNdlovuNNovakRMPerezRios APhanuphakNRamgopalMRuanePJSánchezJSantosBSchinePSchreibmanTSpencerLYVanGerwen OTVasconcelosRVasquezJGZwaneZCoxSDeatonCEbrahimiRWongPSinghRBrownLBCarterCCDasMBaetenJMOgbuaguO; PURPOSE 2 Study Team. Twice-yearly lenacapavir for HIV prevention in men and gender-diverse persons. N Engl J Med 2024; [Epub ahead of print] doi: 10.1056/NEJMoa2411858
|
[10] |
The Lancet HIV . Lenacapavir licenses will not deliver on all opportunities. Lancet HIV 2024; 11(11): e717
CrossRef
Google scholar
|
/
〈 |
|
〉 |