Gynecologic infections seen in ThinPrep cytological test in Wuhan, China

Abstract

This study aimed to analyze the prevalence of bacterial, Candida, Trichomonas, and human papillomavirus (HPV) infections in ThinPrep cytological test (TCT) performed on women of Wuhan, China. ThinPrep smears were screened by two independent experienced pathologists and reported from 2008 to 2010. A total of 46 866 ThinPrep smears were studied, and smears with inflammation were analyzed. Of the 44 162 enrolled patients, inflammation changes were observed in 21 935 (49.7%) and specific infections in 6884 (31.4%). The infections detected were as follows: bacteria, 5663 (82.3%); Candida, 825 (12.0%); Trichomonas, 273 (4.0%); and HPV, 148 (2.1%). Significant changes were found in the prevalence of bacteria and Candida among women who underwent TCT before and after 2010. χ² revealed an increasing proportion of specific infections found in smears after 2010 (P=0.000). In conclusion, bacterial infection was the most detectable in the ThinPrep smears, followed by Candida and Trichomonas. The prevalence of infection identified by TCT was found to be similar in previous literature in China.

Keywords

ThinPrep cytological test / human papillomavirus / Candida infection / Trichomonas infection / bacterial infection

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Acknowledgements

This study was endorsed by the Key Basic Research and Development Program Foundation of China (973 Program; No. 2009CB521800) and was supported by grants from the National Natural Science Foundation of China (Nos. 30973472, 81001151, 81071663, 30973205, 30973184, and 81101964).

Compliance with ethics guidelines

Hang Zhou, Jian Shen, Shaoshuai Wang, Xiong Li, Ru Yang, Yao Jia, Kecheng Huang, Ting Hu, Fangxu Tang, Jin Zhou, Jingping Yuan, Lei Huang, Xun Tian, Zhilan Chen, Qinghua Zhang, Changyu Wang, Ling Xi, Dongrui Deng, Hui Wang, Ding Ma, and Shuang Li declare that they have no conflicts of interest. This article does not contain any studies with human or animal subjects performed by any of the authors.

RIGHTS & PERMISSIONS

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg