Preliminary results of gentamycin combined with
sodium bicarbonate for prevention of irinotecan-induced diarrhea

doi:10.1007/s11684-009-0077-7

PDF(92 KB)

Front. Med. ›› 2009, Vol. 3 ›› Issue (4) : 470-474. DOI: 10.1007/s11684-009-0077-7

Research articles

Preliminary results of gentamycin combined with sodium bicarbonate for prevention of irinotecan-induced diarrhea

Qi MEI MM¹,Zhe CAO MM¹,Hua XIONG MD¹,Yuan CHEN MD²,

Author information +

History +

Abstract

The aim of this paper was to observe the clinical effect of gentamycin combined with sodium bicarbonate for the prevention of irinotecan-induced diarrhea. A total of 98 patients with stage IV cancers were recruited and divided into a prevention group (52 patients) and a control group (46 patients). All patients received the chemotherapy including irinotecan. The prevention group received gentamycin and sodium bicarbonate before the use of irinotecan for 4 days; the control group did not receive any prevention. The use of gentamycin and sodium bicarbonate resulted in significantly higher stool pH (P < 0.001), while the incidence of diarrhea by irinotecan was reduced (prevention group 13.70% versus control group 34.83%; P < 0.001). Gentamycin combined with sodium bicarbonate appears to be useful in preventing the diarrhea induced by irinotecan and reducing the dosage of loperamide and fluid replacement.

Keywords

irinotecan / diarrhea / gentamycin / sodium bicarbonate / prevention

Cite this article

EndNote

Ris (Procite)

Bibtex

Download citation ▾

Qi MEI MM, Zhe CAO MM, Hua XIONG MD, Yuan CHEN MD,. Preliminary results of gentamycin combined with sodium bicarbonate for prevention of irinotecan-induced diarrhea. Front. Med., 2009, 3(4): 470‒474 https://doi.org/10.1007/s11684-009-0077-7