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2018年, 第12卷 第4期
Killing mechanisms of NK cell against tumor cells. Upon the formation of immunological synapse between activated NK cell and tumor cell, multiple killing mechanisms can be triggered, including direct killing of the tumor cell by the (A) release of granules containing perforin and granzymes and (B) induction of apoptosis through the ligation of Fas-FasL or TRAIL-TRAIL ligand, and indirect killing through (C) the secretion of factors that recruit and promote the activation of other inflammatory cells that indirectly kill a target cell. (Courtesy of Drs. Weihua Xiao and Zhigang Tian. See pages 440?450 by Fang Fang et al. for more information.)[展开] ...