Exploring the immunological impact of particles across dimensions in antigen and drug delivery systems

Abstract

Particle formulation engineering stands as a focal point of research and a critical trajectory within the chemical industry. In response to the challenges associated with antigen/drug delivery, our research group has proposed a suite of strategies centered on micro/nanoparticle platforms. This review integrates our investigations into the applications of particles across various dimensions in biomedical delivery systems. Specifically, it delineates the mechanisms by which particles augment vaccine-induced immune responses, notably through antigen cross-presentation, and the pivotal roles they play in facilitating drug-mediated targeting of cancer cells via confined mass transfer. This review also encompasses recent advancements in particle formulations, offering prospective insights into the utilization of chemical engineering principles in the design of next-generation biomedical delivery systems.

Graphical abstract

Keywords

micro/nanoparticles / graphene oxide / precise drug delivery / vaccine adjuvant

RIGHTS & PERMISSIONS

Higher Education Press