Solvates and polymorphs of clindamycin phosphate: Structural, thermal stability and moisture stability studies

Abstract

Clindamycin phosphate (CP), an antibacterial agent, has been reported to form several solid-state forms. The crystal structures of two CP solvates, a dimethyl sulfoxide (DMSO) solvate and a methanol/water solvate (solvate V), have been determined by single crystal X-ray diffraction. The properties and transformations of these forms were characterized by powder X-ray diffraction, Single-crystal X-ray diffraction, differential scanning calorimetry, thermo gravimetric analysis, hot-stage microscopy, and dynamic vapor sorption. Very different hydrogen bonding networks exist among the host-host and host-solvent molecules in the two crystal structures, resulting in different moisture stabilities. The thermal stabilities of the two solvates upon heating and desolvation were also studied. When the temperature was above the boiling point of methanol, solvate V converted to a polymorphic phase after a one step desolvation process, whereas the desolvation temperature of the DMSO solvate was below the boiling point of DMSO. At the relative humidity above 43%, the DMSO solvate transformed to a hydrate at 25 °C. In contrast, solvate V did not transform at any of the humidities studied.

Graphical abstract

Keywords

clindamycin phosphate / solvate / crystal structure / thermal stability / moisture stability

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Acknowledgments

The authors are grateful for the financial support from the National Natural Science Foundation of China (Grant Nos. 81361140344 and 2136164), the National High Technology Research and Development Program of China (2015AA021002) and the Major National Scientific Instrument Development Project (No.21537812).

Electronic Supplementary Materialƒ

Supplementary material is available in the online version of this article at http://dx.doi.org/10.1007/s11705-017-1624-4 and is accessible for authorized users.

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