Nucleation and growth mechanism of cefodizime sodium at different solvent compositions

Abstract

The induction time of cefodizime sodium was measured in ethanol-water at different solvent compositions by the laser technology measurement. The results indicate that the solvent composition played an important role in the supersaturation and the nucleation process of cefodizime sodium solution. According to the modified classical nucleation theory, the nucleation and growth mechanism were identified. The correlation results show that heterogeneous nucleation dominated the nucleation process at lower supersaturation, where homogeneous nucleation is the most important mechanism at higher supersaturation. Based on the correlated results, the 2D mediated growth mechanism had the highest correlation coefficients (R²), so this mechanism was selected as the proper growth mechanism for cefodizime sodium.

Keywords

cefodizime sodium / induction time / primary nucleation / growth mechanism

References

[1] Mullin J W. Crystallization, 3rd Edition. Butterworth-Heinemann: Oxford, 2000, 73-76

[2] Marunaka T, Matsushima E, Minami Y, Azuma R, Yoshida K, Umeno Y. Acidic degradation of cefodizime (THR-221) and structural elucidation of the products. I. Chemical & Pharmaceutical Bulletin, 1989, 37(2): 367-372

[3] Bryskiera T P, Labrob M T. Cefodizime, a new 2-aminothiazolyl cephalosporin: Physicochemical properties, toxicology and structure-activity relationships. Journal of Antimicrobial Chemotherapy, 1990, 26(Suppl C): 1-8

[4] Zhang X W, Yin Q X, Cui P L, Liu Z K, Gong J B. Correlation of solubilities of hydrophilic pharmaceuticals versus dielectric constants of binary solvents. Industrial & Engineering Chemistry Research, 2012, 51(19): 6933-6938

[5] Martin W. US Patent, 5126445, 1992-6-30

[6] Cui P L, Zhang X W, Yin Q X, Gong J B. Evidence of hydrogen-bond formation during crystallization of cefodizime sodium from induction-time measurements and in situ raman spectroscopy. Industrial & Engineering Chemistry Research, 2012, 51(42): 13663-13669

[7] Hao H X, Wang J K, Wang Y L. Determination of induction period and crystal growth mechanism of dexamethasone sodium phosphate in methanol-acetone system. Journal of Crystal Growth, 2005, 274(3-4): 545-549

[8] Anuj K, Glen S K, Geoff G Z Z. Determining the growth mechanism of tolazamide by induction time measurement. Crystal Growth & Design, 2007, 7(2): 234-242

[9] Mahajan A K, Kirwan D J. Nucleation and growth kinetics of biochemicals measured at high supersaturations. Journal of Crystal Growth, 1994, 144(3-4): 281-290

[10] Lancia A, Musmarra D, Prisciandaro M. Measuring induction period for calcium sulfate dihydrate precipitation. AIChE Journal. American Institute of Chemical Engineers, 1999, 45(2): 390-397

[11] Zhang Y F, Li Y H, Zhang Y. Supersolubility and induction of aluminosilicate nucleation from clear solution. Journal of Crystal Growth, 2003, 254(1-2): 156-163

[12] El-Shall H, Jeon J, Abdel-Aal E A, Khan S, Gower L, Rabinovich Y. Jeon Jin-hwan, Abdel-Aal E A, Khan S, Gower L, Rabinovich Y. A study of primary nucleation of calcium oxalate monohydrate. I: Effect of supersaturation. Crystal Research and Technology, 2004, 39(3): 214-221

[13] Liu X J, Xu D, Ren M J, Zhang G H, Wei X Q, Wang J. An examination of the growth kinetics of L-arginine trifluoroacetate (LATF) crystals from induction period and atomic force microscopy investigations. Crystal Growth & Design, 2010, 10(8): 3442-3447

[14] Roger A G, Christelle D, Sandra G, Rasmuson A C. Primary nucleation of paracetamol in acetone-water mixtures. Chemical Engineering Science, 2001, 56(7): 2305-2313

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2014 Higher Education Press and Springer-Verlag Berlin Heidelberg