Multiphase surfactant-assisted reaction-separation system in a microchannel reactor

Salah ALJBOUR, Tomohiko TAGAWA, Mohammad MATOUQ, Hiroshi YAMADA

PDF(213 KB)
PDF(213 KB)
Front. Chem. Sci. Eng. ›› 2009, Vol. 3 ›› Issue (1) : 33-38. DOI: 10.1007/s11705-009-0108-6
RESEARCH ARTICLE

Multiphase surfactant-assisted reaction-separation system in a microchannel reactor

Author information +
History +

Abstract

The Lewis acid-catalyzed addition of trimethylsilyl cyanide to p-chlorobenzaldehyde in a microchannel reactor was investigated. The microchannel was integrated to promote both reaction and separation of the biphase system. FeF3 and Cu(triflate)2 were used as water-stable Lewis acid catalysts. Sodium dodecyl sulfate was incorporated in the organic-aqueous system to enhance the reactivity and to manipulate the multiphase flow inside the microchannel. It was found that the dynamics and the kinetics of the multiphase reaction were affected by the new micellar system. Parallel multiphase flow inside the microchannel was obtained, allowing for continuous and acceptable phase separation. Enhanced selectivity was achieved by operating at lower conversion values.

Keywords

Lewis acid catalysis / multiphase reactions / process intensification / microchannel reactor / green engineering

Cite this article

Download citation ▾
Salah ALJBOUR, Tomohiko TAGAWA, Mohammad MATOUQ, Hiroshi YAMADA. Multiphase surfactant-assisted reaction-separation system in a microchannel reactor. Front Chem Eng Chin, 2009, 3(1): 33‒38 https://doi.org/10.1007/s11705-009-0108-6

References

[1]
Li C-J. Organic reactions in aqueous media with a focus on carbon-carbon bond formation. Chem Rev, 1993, 93: 2023-2035
CrossRef Google scholar
[2]
Lindstrom U M. Stereoselective organic reactions in water. Chem Rev, 2002, 102: 2751-2772
CrossRef Google scholar
[3]
Kobayashi S, Nagayama S, Busujima T. Lewis acid catalysis in aqueous media: copper (II)-catalyzed aldol and allylation reactions in a water-ethanol-toluene solution. Chem Lett, 1997: 959-960
CrossRef Google scholar
[4]
Kobayashi S, Wakabayashi T, Nagayama S, Oyamada H. Lewis acid catalysis in micellar systems: Sc(OTf)3-catalyzed aqueous aldol reactions of silyl enol ethers with aldehydes in the presence of a surfactant. Tetrahedron Letters, 1997, 38: 4559-4562
CrossRef Google scholar
[5]
Killer E, Feringa B L. Highly efficient ytterbium triflate catalyzed michael addition of nitroesters in water. Synlett, 1997: 842
CrossRef Google scholar
[6]
Otto S, Bertoncin F, Engberts B F N. Lewis acid catalysis of a Diels-Alder reaction in water. J Am Chem Soc, 1996, 118: 7702-7707
CrossRef Google scholar
[7]
Bandgar B P, Kamble V T. Organic reactions in aqueous medium: FeF3catalyzed chemoselective addition of cyanotrimethylsilane to aldehydes. Green Chemistry, 2001, 3: 265-266
CrossRef Google scholar
[8]
Tagawa T, Aljbour S, Matouq M, Yamada H. Micro-channel reactor with guideline structure for organic aqueous binary system. Chem Eng Sci, 2007, 62: 5123-5126
CrossRef Google scholar
[9]
Baroud C N, Willaime H. Multiphase flows in microfluidics. C R Physique, 2004, 5: 547-555
[10]
Shui L, Eijkel J C T, van den Berg A. Multiphase flow in microfluidic systems: control and applications of droplets and interfaces. Advances in Colloid and Interface Science, 2007, 133: 35-49
CrossRef Google scholar
[11]
Guuillot P, Colin A. Stability of parallel flows in a microchannel after a T junction, Physical Review, 2005, 72: <patent>066301</patent>
CrossRef Google scholar
[12]
Reddy V, Zahn J D. Interfacial stabilization of organic-aqueous two-phase microflows for a miniaturized DNA extraction. Journal of Colloid and interface Science, 2005, 286: 158-165
[13]
Kashid M N, Platte F, Agar D W, Turek S. Computational modelling of slug flow in a capillary microreactor. Journal of Computational and Applied Mathematics, 2007, 203: 487-497
CrossRef Google scholar
[14]
Ahmed B, Barrow D, Wirth T. Enhancement of reaction rates by segmented fluid flow in capillary scale reactors. Adv Synth Catal, 2006, 348: 1043-1048
CrossRef Google scholar

Acknowledgements

Mr. Hajime Itoh from Nagoya University is highly acknowledged for his valuable technical assistance and advice.
Nomenclature
Ca  Capillary number, –
μ  The viscosity of the continuous phase, Pa•s
U  The flow velocity, m•s–1
σ  The interfacial tension, N•m–1

RIGHTS & PERMISSIONS

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg
AI Summary AI Mindmap
PDF(213 KB)

Accesses

Citations

Detail

Sections
Recommended

/