Chromosomal studies were carried out in 30 patients including 28 cases of leukemia and 2 cases of myelofibrosis. 25 of them were studied by trypsin-Giemsa banding technique and the other 5 by ordinary Giemsa stain. 19 of the 30 cases showed chromosomal abnormalities. All of the 9 cases of chronic myelocytic leukemia (CML) had Ph1 chromosome and 8 of them were proved to have typical 9:22 translocation. 4 cases in the blastic stage of CML also had Ph1 chromosome and in 3 of them additional chromosomal changes were found. Of these three, 2 had double Ph1 and one had a new structural rearrangement which appeared to be t(3:6), (q27, q13-15). Of the 11 cases of acute leukemia 3 had chromosomal abnormalities. One of them was a Ph1 positive acute lymphocytic leukemia (ALL) and the other 2 had gaining or missing in groups C, D or E. Two of the 3 preleukemias had an additional chromosome in group G. One of the two cases of primary myelofibrosis had Ph1 chromosome and a new chromosomal change t (1:11) (p34; q13) was found on entering blastic transformation. One case of lymphosarcoma cell leukemia showed no chromosomal abnormality. Karyotype analysis is described in detail of the two cases with new chromosomal abnormalities. Diagnostic and prognostic significance of chromosomal changes in various types of leukemia is discussed.
This paper presents our parasitological studies on the ancient corpse of Western Han Dynasty unearthed from tomb No. 168 on Phoenix Hill in Jiangling county, Hubei province. It was found that eggs of four species of parasites in it, belong to Schistosoma japonicum, Clonorchis sinensis, Taeniarhynchus saginatus (or Taenia solium), and Trichuris trichiura respectively. This shows that early in 167 B.C. there was prevalence of four kinds of the above-mentioned parasitoses in Jiangling county area. The ancient corpse is recognized as the earliest case of these four parasitic diseases ever reported in the world’s medical literature.
In this paper such questions as the circumstance of Old Yunmong Lake (earlier name) or Jianghan lakes group (recent name), its formation and constitution, and the natural material conditions for prevalence of parasitoses are discussed in detail. Other social and productive factors predisposing to parasitic infections, such as the life style, farm and sideline productive activities of ancient people are also dealt with. Moreover, the special significance of eggshells of parasites in preservation is considered as well.
Diese Arbeit berichtet über die erste erfolgreiche allogene Nierentransplantation bei der Ratte in China. Von Nov. 1980 bis zum 6. April 1981 wurden 39 Experimente durchgeführt. Mit der Zeit verbesserten sich die Resultate. Bei den letzten 14 Transplantationen erreichte die Uberlebensrate 64, 3%; insgesamt überlebten 7 Versuchstiere mindestens 2 Monate lang. Die akute Absto-ßung als Todesursache kam nur 3mal vor. 3 Empfängerratten leben bis jetzt mit ausgezeichneter Nierenfunktion, die am längsten überlebende schon 190 Tage. Die anderen 4 Versuchstiere, die die Transplantation mindestens 2 Monate überlebten, sind alle an Erkrankungen gestorben, die nicht mit der Transplantation zusammenhingen; die histologischen Befunde der Transplantate zeigten bei der Obduktion keine pathologischen Veränderungen. Die wesentlichen Punkte der Operationstechnik werden genau beschrieben und ausführlich diskutiert.
20 Hepatitisfälle im Jahre 1963 waren aufgrund der klinischen und pathologisch-histologischen Befunde als chronisch persistierende Hepatitis im Kindesalter diagnostiziert worden. Sie wurden 12 Jahre später, im Jahre 1975, einer Nachkontrolle unterzogen. Dabei fand man, daß, einen einzigen Fall ausgenommen, die Patienten alle gesund aussahen und einer geregelten Lernbzw. beruflichen Tätigkeit nachgehen konnten. Die Hepato und Splenomegalie gingen zurück, ihre Konsistenz wurde weich und die Leberfunktion normal. Es bestand also keine Neigung zur Leberzirrhose. Andererseits hatten die meisten Patienten im Jahre 1975 noch milde Beschwerden, wie Anorexie, Müdigkeit usw; Schmerzen in der Lebergegend traten sogar häufiger auf. Das bestätigt somit die Richtigkeit unserer Behauptung vom Jahre 1963, daß man sowohl eine gründliche Heilung der Hepatitis als auch deren Entwicklung zu Leberzirrhose bei Kindern selten zu sehen bekommt. Außerdem waren diese Hepatitisfälle oft von extrahepatischen Organmanifestationen begleitet, wie Arthritis, Asthma, Nephritis, Hautexanthemen usw. die meist allergischer Natur waren. Das besagt, daß nicht nur die chronisch aktive, sondern auch die chronisch persistierende Hepatitis zu den Immunkrankheiten gehört; zwischen den beiden Formen besteht ein gradueller, aber kein prinzipieller Unterschied. In der Praxis ist wiederholt ein Übergang von chronisch persistierender zu chronisch aktiver Hepatitis beobachtet worden.
995 patients with atrial fibrillation were treated with digitalis. Of them 167 developed digitalis intoxication in the form of various arrhythmias, and 20 (12%) died of severe intoxication. The occurrence of arrhythmia among rheumatic patients was 20.82%, while among coronary heart disease 10.04%. The types of arrhythmias appeared in the order of following sequences: slow ventricular rate with junctional escapes, complete or almost complete entrance block in AVN, subsequently followed by non-paroxysmal junctional tachycardia and that coexisting with ventricular premature beat in the form of bigeminy, then Wenckebach’s type of exit block, bidirectional tachycardia with possible coexistence of right or left BBB. In addition, various forms of ventricular premature beats, mostly in coupled rhythm occurred.
The identification of digitalis intoxication with atrial fibrillation was illustrated. The characteristics of ECG in junctional escapes, junctional tachycardia and bidirectional tachycardia, etc., were described to facilitate prompt recognition.
A living worm was discharged per urethram of a 26-year-old woman, and identified as Parachordodes sp. based on its morphologic characteristics. This is the sixth case of human urinary infestation with nematomorphs ever reported in the world literature. Her case history, symptoms, treatment were recorded. The morphology of this worm was observed in detail. The route of the invasion of nematomorph was also discussed. It is suggested that the human urinary infestation occurred when the lower body of the patient was immersed into natural waters, such as swamps, ponds, spring-pools, ditches, streams, etc., with the larva or small immature worm entering the urethra, especially of a female patient, and going further into the bladder.
Rhomotoxin is a pharmacologically active principle isolated from the fruits of Rhododendron molle G. Don. Clinical experience demonstrated that it had an antihypertensive effect. In the present work, its haemodynamic effects were studied in anaesthetized open-chest dogs.
| 1. | Rhomotoxin given intravenously (5 μg/kg) lowered the blood pressure, slowed the heart rate and decreased the left ventricular pressure in dogs. In addition, it decreased ±dp/dt max significantly, which indicated that rhomotoxin might be inhibitory to cardiac contractility. This cardiac inhibitory effect was found to be parallel to its hypotensive action. |
| 2. | There is no simultaneous increase, sometimes even a decrease, in left ventricular end diastolic pressure, during the inhibition of contractile performance of the heart by the drug. Hence it was suggested that rhomotoxin might dilate the capacity blood vessels, decrease blood return to the heart and thus decrease the preload of the left ventricle. |
| 3. | The drug had a transient effect in lowering the peripheral blood vessel resistance, which, as shown by intra-femoral artery injection, was not due to its direct vasodilating action. |
| 4. | The haemodynamic effects of rhomotoxin were essentially the same in either vagotomized or intact animals. Thus it seemed unlikely that the action of vagus nerve played any important role in its antihypertensive action. |
This report presents 37 cases of acute leukemias, showing that the skin-window cellular response was markedly reduced. Immature leukemic cells were not found in the exudates. Acellular response and “delayed” cellular response should be of a prognostic significance.
Chemotherapeutic agents and adrenocorticosteroid do rot per se depress the cellular response and phagocytic ability in induced inflammatory exudates.
Im Gebiet von Hubei haben wir 86 Fälle von Conjunctivitis vernalis klinisch und zytologisch genau untersucht und erkannten dabei, daß diese Krankheit in der täglichen Praxis ziemlich häufig falsch diagnostiziert wird. Sie wird leicht mit Trachom, Phlyktäne und chronischer katarrhalischer Konjunktivitis verwechselt. In den Abstrichpräparaten entdeckten wir zwei für Conjunctivitis vernalis charakteristische Formen von Epithelzellenwir nennen sie lockerkernige Epithelzellen und Seidennetz-Epithelzellen; man kann die beiden als diagnostische Hilfsmerkmale benutzen. Außerdem sind auch die aufgeplatzten eosinophilen Leukozyten von diagnostischer Bedeutung.
Tetrandrine (T), an alkaloid isolated from the root of Stephania tetrandra S. Moore, possessed an antihypertensive, antianginal and antiarrhythmogenic effect.
This paper studied the direct influence of tetrandrine upon the contractility, automaticity, excitability and refractory period of isolated atrium of guinea pigs.
| 1. | Tetrandrine 32 uM decreased the contractility, ±dT/dt max and automaticity and prolonged the functional refractory period (FRP), but exerted no influence upon its excitability. |
| 2. | The decrease in automaticity and prolongation of refractory period were thought to be ascribed to its antiarrhythmic action. |
| 3. | The negative inotropic and automaticitic effects suggested that tetrandrine might be antagonistic to Ca++. |