Investigation of cellular migration in acute leukemia: An observation on “Skin-window” exudates in 37 cases

Abstract

This report presents 37 cases of acute leukemias, showing that the skin-window cellular response was markedly reduced. Immature leukemic cells were not found in the exudates. Acellular response and “delayed” cellular response should be of a prognostic significance.

Chemotherapeutic agents and adrenocorticosteroid do rot per se depress the cellular response and phagocytic ability in induced inflammatory exudates.

Keywords

acute leukemia / “skin-window” / acellular response / “delayed” cellular response

References

[1] 8: 370, 1974

[2] BoggsDR, et al. . The effect of adrenal glucocorticosteroids upon the cellular composition of inflammatory exudates. Am J Pathol, 1964, 44763-763

[3] PerilliePE, FinchSC. Quantitative studies of the local exudative cellular reaction in acute leukemia. J Clin Invest, 1964, 43425-425

[4] Rebuck JW & Leal F: Use of the skin windows in monitoring immunosuppression in man, In “Malignant disease of the hematopoietic system”, p55, Tokyo University Press, 1973

[5] 1: 155, 1964

[6] PickeringLK, et al. . Effect of chemothcrapeutic agents on metabolic and bactericidal activity of polymorphonuclear leukocytes. Cancer, 1978, 421741-1741

[7] SasadaM, et al. . Phagocytic and bactericidal capacities in neutrophils from patients with acute and chronic myelocytic leukemia. Acta Haematol Jpn, 1978, 41709-709

[8] NorrisDA, et al. . Monocyte chemotaxis in leukemia patients. J Lab Clin Med, 1980, 95609-609

[9] SnydermanR, et al. . Human mononuclcar leukocyte chemotaxis: a quantitative assay for humoral and cellular chemotactic factors. J Immunol, 1972, 108857-857