Forensic Study on Objective Evaluation of Visual Acuity of Ametropia with the Event-related Potential P3

Abstract

Objective

In this study, we aimed to assess the characteristics of the P3 component from an event-related potential (ERP) that was induced by visual acuity (VA) processing. Furthermore, we sought to provide electrophysiological evidence for the objective evaluation of VA.

Methods

We recruited 32 participants with myopia-related ametropia. They reported no other ocular diseases and had an uncorrected VA of 4.0 in both eyes. We used the block letter “E” at different visual angles and orientations as the graphic stimuli. The oddball paradigm, consisting of 4 modules, was used for ERP analysis. The standard stimuli of each module were identical, with a visual angle of 1°15′. The visual angles of the target stimuli were 1°15′, 55′, 24′, and 15′. The VA test was performed on each eye separately for all participants, and all characteristics of the P3 component were analyzed.

Results

There was no significant difference in the P3 peak letencies between the target stimulation angle 1°15′ group and the 55′ group, or between the target stimulation angle 24′ group and the 15′ group. There was a significant difference in the P3 peak letencies between the target stimulation angle 1°15′ group and the 24′ group as well as the 15′ group. There was a significant difference in the P3 peak letencies between the target stimulation angle 55′ group and the 24′ group as well as the 15′ group. No significant differences were observed in the P3 amplitude between modules.

Conclusion

In the oddball paradigm, P3 elicitation indicated a cognitive response to the target stimuli. These data showed that the characteristics of P3 can be used as an objective evaluation of VA.

Keywords

event-related potential / P3 / visual acuity / forensic medicine / amplitude

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